Enhanced Glutamatergic Synaptic Plasticity in the Hippocampal CA1 Field of Food-Restricted Rats: Involvement of CB1 Receptors

Talani, Giuseppe; Licheri, Valentina; Biggio, Francesca; Locci, Valentina; Mostallino, Maria Cristina; Secci, Pietro Paolo; Melis, Valentina Maria; Dazzi, Laura; Carta, Gianfranca; Banni, Sebastiano; Biggio, Giovanni; Sanna, Enrico

doi:10.1038/npp.2015.280

Cited by 22 publications

(20 citation statements)

References 43 publications

(51 reference statements)

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“…Rats or mice that run or are fasted intermittently exhibit enhanced LTP at hippocampal synapses compared with sedentary animals fed ad libitum 27–29 . Daily TRF (22 hours of fasting every day) for 3 weeks improves performance in the Barnes maze test and increases dendritic spine density and LTP in CA1 neurons in rats 30 . IMS can also prevent age-related deficits in LTP 31,32 .…”

Section: Neuronal Adaptations To Imsmentioning

confidence: 95%

Intermittent metabolic switching, neuroplasticity and brain health

et al. 2018

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During evolution, individuals whose brains and bodies functioned well in a fasted state were successful in acquiring food, enabling their survival and reproduction. With fasting and extended exercise, liver glycogen stores are depleted and ketones are produced from adipose-cell-derived fatty acids. This metabolic switch in cellular fuel source is accompanied by cellular and molecular adaptations of neural networks in the brain that enhance their functionality and bolster their resistance to stress, injury and disease. Here, we consider how intermittent metabolic switching, repeating cycles of a metabolic challenge that induces ketosis (fasting and/or exercise) followed by a recovery period (eating, resting and sleeping), may optimize brain function and resilience throughout the lifespan, with a focus on the neuronal circuits involved in cognition and mood. Such metabolic switching impacts multiple signalling pathways that promote neuroplasticity and resistance of the brain to injury and disease.

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Section: Neuronal Adaptations To Imsmentioning

confidence: 95%

Intermittent metabolic switching, neuroplasticity and brain health

et al. 2018

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“…A number of previous studies suggest that FR (DR/CR) may lead to alterations of hippocampus (Benau et al, 2014; Conrad, 2010), which further contribute to changes of memory (Partadiredja and Bedi, 2011). For example, FR altered hippocampal CB1R expression and function in rats (Talani et al, 2016), and CR enhanced hippocampal neurogenesis and remote contextual fear memory in adult mice (Hornsby et al, 2016). Regarding the developing phase, it was published recently that young‐onset CR could result in alterations of neurogenesis in the dentate gyrus, which may explain some impairment of spatial cognition (Cardoso et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Food restriction affects Y‐maze spatial recognition memory in developing mice

Chen

et al. 2017

Intl J of Devlp Neuroscience

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The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals.

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“…However, in non-stressed rats, CB 1 activation reduced the excitatory post-synaptic currents. In addition, Talani et al ( 2016 ) mimicked the effects of food restriction on glutamate release, LTP induction, and BDNF release in the hippocampus, by blocking CB 1 receptors. Hu et al ( 2011 ) showed that rats exposed to chronic restraint stress presented an impaired endocannabinoid-mediated DSI in the CA 1 pyramidal neurons of the dorsal hippocampus.…”

Section: Stress Induces Changes In Cannabinoid-mediated Hippocampal Nmentioning

confidence: 99%

Cannabinoid Modulation of the Stressed Hippocampus

Scarante

Vila-Verde

Detoni

et al. 2017

Front. Mol. Neurosci.

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Exposure to stressful situations is one of the risk factors for the precipitation of several psychiatric disorders, including Major Depressive Disorder, Posttraumatic Stress Disorder and Schizophrenia. The hippocampal formation is a forebrain structure highly associated with emotional, learning and memory processes; being particularly vulnerable to stress. Exposure to stressful stimuli leads to neuroplastic changes and imbalance between inhibitory/excitatory networks. These changes have been associated with an impaired hippocampal function. Endocannabinoids (eCB) are one of the main systems controlling both excitatory and inhibitory neurotransmission, as well as neuroplasticity within the hippocampus. Cannabinoids receptors are highly expressed in the hippocampus, and several lines of evidence suggest that facilitation of cannabinoid signaling within this brain region prevents stress-induced behavioral changes. Also, chronic stress modulates hippocampal CB1 receptors expression and endocannabinoid levels. Moreover, cannabinoids participate in mechanisms related to synaptic plasticity and adult neurogenesis. Here, we discussed the main findings supporting the involvement of hippocampal cannabinoid neurotransmission in stress-induced behavioral and neuroplastic changes.

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Enhanced Glutamatergic Synaptic Plasticity in the Hippocampal CA1 Field of Food-Restricted Rats: Involvement of CB1 Receptors

Cited by 22 publications

References 43 publications

Intermittent metabolic switching, neuroplasticity and brain health

Intermittent metabolic switching, neuroplasticity and brain health

Food restriction affects Y‐maze spatial recognition memory in developing mice

Cannabinoid Modulation of the Stressed Hippocampus

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