Enhanced frequency of chromosome aberrations in workers occupationally exposed to diagnostic X-rays

Jha, Awadhesh N.; Sharma, T.

doi:10.1016/0165-1218(91)90020-m

Cited by 68 publications

(36 citation statements)

References 17 publications

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“…The occupationally exposed individuals showed higher frequencies of dicentric and acentric chromosomes compared with the normal controls (Jha and Sharma, 1991). DNA strand breaks accumulate for quite a long time after ionizing radiation exposure, indicating the development of genetic instability and an increase in carcinogenic risk for organisms exposed to a combination of harmful environmental factors (Mikhailenko and Muzalov, 2013).…”

Section: Discussionmentioning

confidence: 99%

Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Zhou¹,

Hao²,

Guo³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Long-term radiation exposure affects human health. Ionizing radiation has long been known to raise the risk of cancer. In addition to high doses of radiation, low-dose ionizing radiation might increase the risk of cardiovascular disease, lens opacity, and some other non-cancerous diseases. Low-and high-dose exposures to ionizing radiation elicit different signaling events at the molecular level, and may involve different response mechanisms. The health risks arising from exposure to low doses of ionizing radiation should be re-evaluated. Health workers exposed to ionizing radiation experience low-dose radiation and have an increased risk of hematological malignancies. Reproductive function is sensitive to changes in the physical environment, including ionizing radiation. However, data is scarce regarding the association between occupational radiation exposure and risk to human fertility. Sperm DNA integrity is a functional parameter of male fertility evaluation. Hence, we aimed to report sperm quality and DNA damage in men from Jilin Province, China, who were occupationally exposed to ionizing radiation. Sperm motility and normal morphology were significantly lower in the exposed compared with the non-exposed men. There was no statistically significant difference in sperm concentration between exposed and non-exposed men. The sperm DNA fragmentation index was significantly higher in the exposed than the non-exposed men. Chronic long-term exposure to low doses of ionizing radiation could affect sperm motility, normal morphology, and the sperm DNA fragmentation index in the Chinese population. Sperm quality and DNA integrity are functional parameters that could be used to evaluate occupational exposure to ionizing radiation.

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Section: Discussionmentioning

confidence: 99%

Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Zhou¹,

Hao²,

Guo³

et al. 2016

Genet. Mol. Res.

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“…There are few studies that assess the genetic effects of human in vivo exposure to radiation using lymphocytes from the peripheral blood. The available data include studies carried out on individuals occupationally exposed to high doses 11,3 ; patients 27 ; people who were accidentally exposed 20,18,6,23 and persons occupationally exposed to low doses of ionizing radiation 9,13,28 . In Brazil, a large group of dentists who are not specialists in radiology deal in their offices with low doses of ionizing radiation without utilizing dosimeters.…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic biomonitoring of Brazilian dentists occupationally exposed to low doses of X-radiation

Miyaji

Cólus

2002

Pesqui. Odontol. Bras.

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Exposure to X-rays (ionizing radiation) may cause chromosomal aberrations (CA) in somatic or germinative cells in exposed individuals, and may lead to manifestations of diseases such as cancer. This study was carried out to assess the CA frequency in lymphocytes obtained by means of temporary culture of peripheral blood from dentists in Londrina, Paraná, Brazil, who have worked for more than ten years with X-rays. The results obtained from the experimental group were compared with a matched negative control group, which had never been exposed to X-rays. All individuals, dentists and controls, answered a personal questionnaire, from which a profile of each group was obtained. Slides, prepared after the cultures, were stained with Giemsa, and 100 to 200 metaphase cells were analyzed per individual. CA frequencies and types were registered and statistical tests were not necessary to evaluate the obtained data. The analysis of mitotic index (MI) did not indicate significant differences (p < 0.05) between the group of individuals exposed to X-rays and the control group. The analyzed confounding factors did not influence the results of MI and CA frequencies. UNITERMS: Chromosome aberrations; Occupational exposure; Mitotic index; Dentist's practice patterns; X-rays. RESUMO:A exposição à radiação ionizante pode causar aberrações cromossômicas (AC) em células somáticas ou germinativas dos indivíduos expostos, podendo levar a manifestações de doenças como os cânceres. Este trabalho teve como objetivo avaliar a freqüência de AC em linfócitos obtidos através de cultura temporária do sangue periférico de dentistas de Londrina (Paraná -Brasil), com mais de dez anos de trabalho com raios X. Os resultados obtidos do grupo experimental foram comparados com um grupo controle negativo pareado, que nunca se expôs ocupacionalmente aos raios X. Todos os indivíduos, dentistas e controles, responderam a um questionário pessoal, a partir do qual foi obtido um perfil de cada grupo. Após as culturas, as lâminas foram confeccionadas, coradas com solução de Giemsa e foram analisadas de 100 a 200 células metafásicas por indivíduo, anotando-se as freqüências e tipos de AC encontrados. Não foi necessária a realização de testes estatísticos para avaliação desses parâmetros. A análise dos índices mitóticos (IM) não indicou diferenças significantes (p < 0,05) entre os indivíduos dos grupos expostos e controle. Os fatores de variação analisados não influenciaram os resultados obtidos para o IM e freqüência de AC.

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“…Numerous studies deal with ionising radiation exposure of individuals who are chronically professionally exposed to low doses (Andreassi, 2009;Au, 1991;Carrano & Natarajan, 1988;Kassie et al, 2000). The results showed the increase in chromosomal damage during chronically low dose exposure (Barquinero et al, 1993;Boutcher, 1985;Cardoso et al, 2001;Jha, 1991;Nowak & Jankowski, 1991), but without confirmed relationship between the received dose and the intensity of DNA damage (Bolus, 2001;Coates et al, 2004;Morgan, 2003;Mothersill et al, 2000Mothersill et al, , 2001Seymour & Mothersill, 2000). The influence of chronically low dose exposure has been considered mutagenic and cancerogenic (Fachini et al, 2009).…”

Section: Introductionmentioning

confidence: 96%

The Influence of Individual Genome Sensitivity in DNA Damage Repair Assessment in Chronic Professional Exposure to Low Doses of Ionizing Radiation

Milić¹,

Rozgaj²,

Kašuba³

et al. 2011

Selected Topics in DNA Repair

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Enhanced frequency of chromosome aberrations in workers occupationally exposed to diagnostic X-rays

Cited by 68 publications

References 17 publications

Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Cytogenetic biomonitoring of Brazilian dentists occupationally exposed to low doses of X-radiation

The Influence of Individual Genome Sensitivity in DNA Damage Repair Assessment in Chronic Professional Exposure to Low Doses of Ionizing Radiation

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