Enhanced Frequency of CD19+IL-10+B Cells in Human Gastric Mucosa Infected by Helicobacter pylori

Nahid‐Samiei, Mahboobeh; Rahimian, Ghorbanali; Shafigh, Mohammadhadi; Taheri, Fatemeh; Karami-Hurestani, Mohammad; Sanaei, Mohammad‐Javad; Heshmati, Masoud

doi:10.1016/j.amjms.2020.03.019

Cited by 23 publications

(14 citation statements)

References 32 publications

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“…IL-10 is currently considered an antiinflammatory peptide implicated in the downregulation of human intestinal immune responses. However, enhanced secretion of IL-10 has been demonstrated in gastric mucosae from Hp-infected patients more than in uninfected individuals, confirming the multifaceted functions of IL-10 [38]. The correlation between IL-10 and macrophage score found in our study suggests the cellular origin of IL-10 in chronic gastritis and considers multiple effects of IL-10 on other proinflammatory cytokine secretion.…”

Section: Discussionsupporting

confidence: 83%

Tissue transglutaminase is involved in the inflammatory processes of active chronic gastritis

Riezzo

Orlando

Clemente

et al. 2021

ARCH BIOL SCI BELGRA

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Since tissue transglutaminase-2 (TG2) can represent a marker of inflammation for some gastrointestinal (GI) diseases, we aimed to evaluate TG2 and inflammatory markers? mucosal content in gastric antrum biopsies to shed light on the histological and biochemical background of chronic gastritis inflammation. Fifty-one of 78 patients who underwent upper GI endoscopy (UGIE) for dyspeptic symptoms, had a gastric biopsy. The symptom profile was assessed by a GI symptom rating scale (GSRS) score. Thirtyfive patients (69%) showed chronic gastritis. TG2, interleukin-6 (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-?, lipopolysaccharides (LPS) and toll-like receptor (TLR)-4 were evaluated in serum and the culture medium of gastric biopsies. TG2, IL-8, IL-10, TLR-4 and TNF-? were significantly higher in active chronic gastritis than in the inactive one and were linked to macrophage concentration. IL-6 was significantly lower in the active form of chronic gastritis than in the inactive one and negatively correlated with TG2. Lastly, IL- 10 significantly correlated with the macrophage score. TG2 can exert an active role in chronic gastritis pathogenesis by cooperating with different markers of inflammation. It seems that TG2 can represent a possible therapeutic target for modulating inflammation and disease progression.

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Section: Discussionsupporting

confidence: 83%

Tissue transglutaminase is involved in the inflammatory processes of active chronic gastritis

Riezzo

Orlando

Clemente

et al. 2021

ARCH BIOL SCI BELGRA

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“…The mucosal TNF-α mRNA expression had a signi cant negative correlation with the frequency of Treg lymphocytes in the PUD group. Our previous study showed that the frequency of Treg and Breg lymphocytes remarkably increased in gastritis patients rather than PUD patients [2,27]. The ndings suggest that increased levels of TNF-α mRNA in H. pylori-infected patients may act an axial role in PUD pathogenesis.…”

Section: Discussionmentioning

confidence: 86%

“…Helicobacter pylori (H. pylori) is a bacterial infection that causes stomach in ammation leading to a diversity of upper gastrointestinal disorderliness such as peptic ulcer disease (PUD), gastritis, and gastric cancer (GC) and mucosa-associated lymphoid tissue (MALT) lymphoma [1]. This infection is related with histological gastritis and signi cant penetration of immune cell such as neutrophils, monocytes and lymphocytes (T and B cells) into the human gastric mucosa, which contribute toward maintaining as well as increasing the gastric in ammation [2,3]. Activation and recruitment of immune cells site of infection is associated with the in ammatory process and the related cytokine production that can lead to gastric in ammation and subsequently causes gastric mucosal damage [4,5].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Mucosal TNF-α Expression and Th1, Th17, Th22 and Treg Responses in Helicobacter Pylori Infection

Rahimian

Abadi

Ahmadi

et al. 2021

Preprint

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Background: Helicobacter pylori (H. pylori) -induced gastric inflammation in the gastric mucosa and significantly increases the risk of developing gastritis and peptic ulcer disease (PUD). The objective of this research is to determine the role of tumor necrosis factor-α (TNF-α) expression in the gastric mucosa of patients with H. pylori –associated gastritis and PUD compared to uninfected patients, and we determined the relation between TNF-α expression and Th1/Th17/Th22, and Treg cells.Methods: Fifty-five patients with H. pylori –associated gastritis, 47 patients with H. pylori –associated PUD, and 48 uninfected patients were in this research. Antrum biopsy was used to detect H. pylori, virulence factors and histopathological assessments.Results: Expression of TNF-α in the infected group was significantly higher than the uninfected group. Also, cagA/oipA-positive infected patients induce significantly more TNF-α expression than do cagA/oipA-negative infected patients. Expression of TNF-α was significantly increased in the PUD group than the gastritis group. Notably, TNF-α expression had a significant positive correlation with the frequency of Th1/Th17/Th22 lymphocytes in the PUD group.Conclusion: These findings indicate the importance of increasing TNF-α with Th1, Th17, Th22 responses increase as an important risk factor for PUD in context of H. pylori infection.

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“…H. pylori is a major human pathogen which produces inflammation of the stomach and is etiologically related to chronic gastritis and PUD, but not all H. pylori -positive subjects develop such diseases [ 20 , 21 , 22 ]. Approximately 50 percent of the human population worldwide is chronically infected with H. pylori without any clinical symptoms and there are significant variations in its prevalence between different countries [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Frequency of virulence-associated genotypes of Helicobacter pylori and their correlation with clinical outcome and histological parameters in infected patients

Abadi

Ashrafi-Dehkordi

Ahmadi

et al. 2021

Heliyon

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Helicobacter pylori ( H. pylori ) is a gram-negative which can cause several gastroduodenal diseases, including gastritis and peptic ulcer disease (PUD). H. pylori specific genotypes have been related to increased occurrence of gastritis and PUD. The aim of this study was to investigate the clinical relevance of the major virulence factors of H . pylori with clinical outcomes and histological parameters in Iranian patients. Totally, 200 subjects with PUD and gastritis disease who underwent gastroduodenal endoscopy were enrolled in this study. The presence of the cagA , vacA , oipA , babA2 , and iceA genes in antral gastric biopsy specimens were determined by polymerase chain reaction (PCR) and the results were compared with clinical outcomes and histological parameters. The frequency of babA2 + , oipA + , vacA s1/m2 , and vacA m2 genes was significantly higher in patients with peptic ulcer disease compared with patients with gastritis. In contrast, the frequency of vacA s1/m1 gene was significantly higher in gastritis subjects than PUD subjects. The high-density scores of H. pylori were strongly associated with iceA1 ¯ , babA2 + , and oipA + genes. Additionally, the high polymorphonuclear cell infiltration and high mononuclear cell infiltration scores were strongly associated with the cagA + , iceA1 ¯ , oipA + genes and cagA + , babA2 + , oipA + genes, respectively. Our study indicated that the vacA , babA2 , and oipA virulence factors are related to a higher risk of PUD in subjects with H. pylori -infection. Infection with these strains was associated with a more severe gastropathy.

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Enhanced Frequency of CD19+IL-10+B Cells in Human Gastric Mucosa Infected by Helicobacter pylori

Cited by 23 publications

References 32 publications

Tissue transglutaminase is involved in the inflammatory processes of active chronic gastritis

Tissue transglutaminase is involved in the inflammatory processes of active chronic gastritis

Relationship Between Mucosal TNF-α Expression and Th1, Th17, Th22 and Treg Responses in Helicobacter Pylori Infection

Frequency of virulence-associated genotypes of Helicobacter pylori and their correlation with clinical outcome and histological parameters in infected patients

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