Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers

Tarvainen, Maarit; Sutinen, Riitta; Peltonen, Soili; Mikkonen, Hannu; Maunus, Jaana; Vähä-Heikkilä, Kalle; Lehto, Vesa‐Pekka; Paronen, Petteri

doi:10.1016/s0928-0987(03)00137-4

Cited by 60 publications

(31 citation statements)

References 25 publications

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“…This could reduce the degree of crystallinity and thus increase the P WVP values. OSA and ASA have been shown to plasticize polymer films of ethyl cellulose and potato starch acetate (Tarvainen et al 2003). A plasticizer increases the free volume of a polymer (Tarvainen et al 2003).…”

Section: Free Filmsmentioning

confidence: 99%

Barrier and mechanical properties of modified starches

Jansson

Järnström

2005

Cellulose

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The study addressed starch-based coatings on paper and fabrics. Coated materials and free starch films containing different amounts of a well-established plasticizer (glycerol) or potential plasticizer (mainly polyols) were tested with respect to water vapour permeance (WVPe), water vapour permeability (WVP), glass transition temperature (T g ), and mechanical strength (tensile tests). Both normal and high-amylose potato starch were used. These starches were modified by (a) oxidation, (b) oxidation and hydroxypropylation or (c) oxidation and hydrophobically modified by reaction with octenyl-or alkenyl-substituted succinic acid anhydride. Free films of hydroxypropylated high-amylose potato starch showed a lower WVP than did the corresponding starches based on regular potato starch. The WVP of the hydrophobically modified regular potato starches was substantially higher than that of films of the corresponding hydroxypropylated starches. The expected hydrophobic effect of the succinic acid anhydrides in terms of a reduced WVP could not be observed. When glycerol was used as a plasticizer, about 30 parts (by wt.) per hundred parts of starch were needed in order to reduce the T g and to cause observable changes in the mechanical properties of the free films.

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Section: Free Filmsmentioning

confidence: 99%

Barrier and mechanical properties of modified starches

Jansson

Järnström

2005

Cellulose

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“…They can potentially reduce the resiliency of the polymer and increase the plasticity of the network when the plasticized structure undergoes the stress loadings during tension (15)(16)(17)(18). Although plasticizers are used in various film-coating applications, spray-dried microspheres, beads, pellets, and microcapsule preparations (7,(19)(20)(21)(22)(23)(24), the development and application of plasticizer in a microsphere matrix system as a release modifier is a new area (11,13). Many compounds can act as a plasticizer, including phthalate and phosphate esters, fatty acids, sorbitol, citrate, and glycol derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…Water-soluble and water-insoluble citrate-type plasticizers show different influence on plasticization time, which results in different release rates of the drug (20,21,25). TEC is a commonly used hydrophilic plasticizer with nontoxic and non-irritant structure (23,24). The type and amount of plasticizer affects the drug diffusion rate through the matrix via structural changes.…”

Section: Introductionmentioning

confidence: 99%

Ethylcellulose-Based Matrix-Type Microspheres: Influence of Plasticizer RATIO as Pore-Forming Agent

2011

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Abstract. In this study, ethylcellulose (EC)-based microsphere formulations were prepared without and with triethyl citrate (TEC) content of 10% and 30% by water-in-oil emulsion-solvent evaporation technique. Diltiazem hydrochloride (DH) was chosen as a hydrophilic model drug and used at different drug/polymer ratios in the microspheres. The aim of the work was to evaluate the influence of plasticizer ratio on the drug release rate and physicochemical characteristics of EC-based matrix-type microspheres. The resulting microspheres were evaluated for encapsulation efficiency, particle size and size distribution, surface morphology, total pore volume, thermal characteristics, drug release rates, and release mechanism. Results indicated that the physicochemical properties of microspheres were strongly affected by the drug/polymer ratio investigated and the concentration of TEC used in the production technique. The surface morphology and pore volume of microspheres significantly varied based on the plasticizer content in the formulation. DH release rate from EC-based matrix-type microspheres can be controlled by varying the DH to polymer and plasticizer ratios. Glass transition temperature values tended to decrease in conjunction with increasing amounts of TEC. Consequently, the various characteristics of the EC microspheres could be modified based on the plasticized ratio of TEC.

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“…Films obtained from regenerated cellulose (from cotton linter) by coating Castor oil polyurethane/benzyl konjac glucomannan semi-interpenetrating polymer networks were water resistant and biodegradable (Lu et al, 2004). Ethyl cellulose based aqueous dispersions and solvent based films were plasticized with n-alkenyl succinic anhydrides -2-octenyl succinic anhydride (OSA) and 2-dodecen-1-ylsuccinic anhydride to overcome the brittleness of cellulose films (Tarvainena et al, 2003). Films obtained showed excellent mechanical properties, low permeability, and good flexibility.…”

Section: Use In Corrosion Resistancementioning

confidence: 99%