Abstract:Weight loss following RYGB is associated with an increase in post-prandial plasma BA response due to larger amounts of glycine-conjugated BAs. This suggests up regulation of BA production and conjugation after RYGB.
“…Regardless, Ahmad et al (29) showed that even if fasting plasma bile acid concentrations are unchanged after bariatric surgery, the response to a meal appears to be restored to that of a healthy, lean individual. Nonetheless, the increases seen at 15 months by Werling et al (28) in fasting bile acids are similar to our results for total and unconjugated bile acids. The changes reported in primary bile acids are mixed compared to the current study because they report increases in CDCA but not CA, whereas we see increases in both.…”
Section: Discussionsupporting
confidence: 94%
“…Most early reports describing the changes in bile acid concentrations postoperatively do not detail the individual concentrations and tend to group chemically similar bile acids (eg, primary/secondary, conjugated/unconjugated) for analysis. The largest (n ϭ 63) and most comprehensive study to date by Werling et al (28) examined chemical groups and individual bile acids in the fasted and postprandial states. This study showed increases in fasting total and unconjugated bile acids, which is similar to the current study.…”
Overall findings suggest that bacterially derived bile acids may mediate the early improvements at 1 month after RYGB. Future studies should examine the changes in specific bile acid chemical species after bariatric procedures and bile acid-specific signaling changes.
“…Regardless, Ahmad et al (29) showed that even if fasting plasma bile acid concentrations are unchanged after bariatric surgery, the response to a meal appears to be restored to that of a healthy, lean individual. Nonetheless, the increases seen at 15 months by Werling et al (28) in fasting bile acids are similar to our results for total and unconjugated bile acids. The changes reported in primary bile acids are mixed compared to the current study because they report increases in CDCA but not CA, whereas we see increases in both.…”
Section: Discussionsupporting
confidence: 94%
“…Most early reports describing the changes in bile acid concentrations postoperatively do not detail the individual concentrations and tend to group chemically similar bile acids (eg, primary/secondary, conjugated/unconjugated) for analysis. The largest (n ϭ 63) and most comprehensive study to date by Werling et al (28) examined chemical groups and individual bile acids in the fasted and postprandial states. This study showed increases in fasting total and unconjugated bile acids, which is similar to the current study.…”
Overall findings suggest that bacterially derived bile acids may mediate the early improvements at 1 month after RYGB. Future studies should examine the changes in specific bile acid chemical species after bariatric procedures and bile acid-specific signaling changes.
“…Not surprisingly, LSG exerted the least evident effect on postoperative serum BA levels. According to some authors, the postsurgery increase in serum BAs was associated with an improvement of glucose metabolism [15,[21][22][23][24]. Our findings are consistent with those data, since the levels of serum glucose, insulin, HOMA, and HBA1c at 3 months after the bariatric procedure were significantly lower than those prior to the surgery.…”
Background Bariatric surgery contributes to the improvement in glucose metabolism that may be related to a postoperative increase in serum bile acids (BAs). Three commonly used types of bariatric procedures, laparoscopic sleeve gastrectomy (LSG) (without creation of a bile loop), Roux-en-Y gastric bypass (RYGB), and omega-loop gastric bypass (OLGB) (with creation of shorter 100-150 cm and longer 200-280 cm bile loops, respectively), differ in their effects on glycemic control. The aim of the study was to compare the effects of various bariatric procedures on serum BA concentration and glucose homeostasis. Methods Serum BAs in 26 obese patients were determined by liquid chromatography-mass spectrometry prior to bariatric surgery, as well as 4 days and 3 months thereafter. Results Four days after the surgery, serum concentrations of BAs in LSG and OLGB groups were similar as prior to the procedure, and a slight decrease in serum BAs was observed in the RYGB group. Serum BA level in the LSG group remained unchanged also at 3 months after the surgery, whereas a significant 0.5-and 3-fold increase in this parameter was noted in the RYGB and OLGB groups, respectively. Serum concentration of BAs correlated positively with the length of the bile loop (R = 0.47, p < 0.05). Conclusion The evident improvement of glycemic control observed 3 months after OLGB might be associated with a postoperative increase in serum BAs, resulting from their better absorption from the longer bile loop. However, the changes in serum BAs probably had little or no impact on insulin sensitivity improvement at 4 days post-surgery.
“…Most short-term studies (< 2 months after surgery) report unchanged or decreased levels of total BAs [26][27][28], while most studies reporting data from several months and years after surgery report increased concentrations [18,20,[29][30][31][32]. Our findings are in accordance with the existent literature, and extend the current knowledge by showing that the BA levels apparently continue to increase up to 5 years after RYGB.…”
(2017). Bile acid profiles over 5 years following gastric bypass and duodenal switch -Results from a randomized clinical trial. Surgery for obesity and related diseases. https://doi.org/10.1016/j.soard.2017.05.024Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections.
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