Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women

Suarez, Edward C.; Lewis, James G.; Krishnan, Ranga; Young, Kenneth H.

doi:10.1016/j.psyneuen.2004.01.002

Cited by 168 publications

(126 citation statements)

References 45 publications

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“…Consistent with evidence that negative dispositions are associated with activation of innate inflammatory pathways (e.g., Appels et al, 2000;Maes et al, 1992Maes et al, , 1995Suarez et al, 2003Suarez et al, , 2004 and predict vulnerability to inflammatory disease (for review, see Everson-Rose and Lewis, 2005;Miller et al, 1996), our findings show that individuals who describe themselves as more verbally and physically aggressive have higher levels of plasma CRP and IL-6 than their less antagonistic counterparts. These associations are depicted in Fig.…”

Section: Discussionsupporting

confidence: 87%

Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality

Marsland

Prather

Petersen³

et al. 2008

Brain, Behavior, and Immunity

126

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Recent evidence suggests that individuals with certain personality traits are at elevated risk for chronic systemic inflammation. To date, this literature has focused on the related traits of hostility and negative affect (NA). In this study, we examine the covariation of trait measures of hostility and NA with the inflammatory mediators interleukin-6 and C-reactive protein. We also explore whether observed associations reflect independent contributions of cognitive, affective and behavioral components of hostile dispositions or shared trait variance with global negative affectivity. Subjects were a diverse sample of 855 relatively healthy middle-aged community volunteers (50% male) from the Adult Health and Behavior Project. The Buss and Perry Aggression Questionnaire (BPAQ) and an Abbreviated Cook-Medley Hostility Scale (ACM) were used to measure dimensions of hostility, and the Multidimensional Personality Questionnaire was used to measure trait NA. Regression analyses accounting for demographic characteristics and medical covariates showed a positive relationship of all components of hostility and trait NA with both IL-6 and CRP. After controlling for trait NA, only the behavioral component of hostility was independently associated with the inflammatory markers. The relationships of cognitive and affective components of hostility with inflammatory markers were largely explained by lifestyle factors, particularly body mass index and smoking. In contrast, lifestyle factors did not explain the covariation of hostile behavioral tendencies and inflammation. These findings suggest that unique attributes of aggressive behavioral tendencies account for much of the variability in inflammation associated with hostility and negative emotions, raising the possibility that individuals high in aggression are at increased risk of inflammatory disease.

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Section: Discussionsupporting

confidence: 87%

Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality

Marsland

Prather

Petersen³

et al. 2008

Brain, Behavior, and Immunity

126

View full text Add to dashboard Cite

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“…In another study, they showed that severity of depression was associated with LPS-induced increased serum IL-8 concentration (Suarez et al, 2004). In contrast, however, another study has shown serum MCP-1 and IL-8 concentrations to be lower in MDD diagnosed subjects of a Finnish population as compared to controls (Lehto et al, 2010).…”

Section: Mcp-1 and Il-8 In Depressionmentioning

confidence: 97%

“…Suarez and colleagues (Suarez et al, 2003;Suarez et al, 2004) have conducted two studies that demonstrated increased IL-8 plasma levels in depressed subjects. In one study, they demonstrated that increased severity of depressive symptoms was correlated with increased levels of plasma IL-8 (Suarez et al, 2003).…”

Section: Mcp-1 and Il-8 In Depressionmentioning

confidence: 99%

A review of the relationship between proinflammatory cytokines and major depressive disorder

Young

Bruno

Pomara

2014

Journal of Affective Disorders

358

228

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Cite this article as: Juan Young, Davide Bruno, Nunzio Pomara, A review of the relationship between proinflammatory Cytokines and major depressive disorder, Journal of Affective Disorders, http://dx.doi.org/10. 1016/j.jad.2014.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…With this and previous work described above in mind, in the current study we hypothesized that stress reactivity, aggression, and alienation would be positively associated with IL-6, CRP, and fibrinogen, while control, traditionalism, and harm avoidance would be negatively associated with the three inflammatory markers. Previous studies suggest that negative dispositional traits such as depression, anxiety, and hostility are positively associated with IL-6 (Suarez, Lewis, Krishnan, & Young, 2004). Therefore, in this current study, we expected that high stress reactivity, aggression, and alienation would lead to higher levels of all three inflammatory markers.…”

Section: Personality and Inflammationmentioning

confidence: 77%

Physical Activity Mediates the Association between Personality and Biomarkers of Health

Graham¹,

Bastarache²,

Milad³

et al. 2017

Preprint

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The current study investigated whether personality traits and facets predicted levels of Interleukin-6, C-reactive protein, and Fibrinogen and whether physical activity mediated the relationship between personality and these biomarkers of health. High harm avoidance and low neuroticism were associated with elevated IL-6, while high social potency, high control, and low achievement were associated with elevated FGN. Mediation models suggested that physical activity mediated the association between higher levels of achievement and lower IL-6. Physical activity is an important factor in the health behavior model, and explains some of the associations between personality and downstream inflammation.

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Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women

Cited by 168 publications

References 45 publications

Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality

Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality

A review of the relationship between proinflammatory cytokines and major depressive disorder

Physical Activity Mediates the Association between Personality and Biomarkers of Health

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