Enhanced expiratory rebreathing space for high loop gain sleep apnea treatment
Thomas Quinn,
Robert Joseph Thomas,
Eric James Heckman
Abstract:The pathophysiology of sleep apnea goes beyond anatomic predisposition to airway collapse and includes additional factors such as arousal threshold and loop gain. High loop gain is a prominent feature in central and complex sleep apnea (with a mixture of obstructive and central features) where relative hypocapnia can lead to respiratory instability and periodic breathing. Existing therapies, including continuous positive airway pressure (CPAP) and adaptive servo-ventilators, often inadequately treat sleep apne… Show more
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