Abstract:The fusion pore controls the release of exocytotic vesicles contents through a precise orchestration of lipids from the fusing membranes and proteins. There is a major lipid reorganization during the different stages in life of the fusion pore: membrane fusion, nucleation and expansion, that can be scrutinized thermodynamically. In this work, using restrained molecular dynamics simulations we describe the expansion of the fusion pore. We have calculated free energy profiles to drive a nascent, just nucleated, … Show more
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