Enhanced Exosome Immunodetection by Integration of Silica Inverse Opal Architectures as Nanostructured Sensors in Quartz Crystal Microbalance with Dissipation Monitoring
Abstract:Exosomes are nanosized circulating vesicles that contain biomarkers considered promising for early diagnosis within neurology, cardiology and oncology. Recently, acoustic wave biosensors, in particular based on quartz crystal microbalance with dissipation monitoring (QCM-D), have emerged as a sensitive, label-free, and selective exosome characterisation platform. A rational approach to further improving sensing detection limits relies on the nanostructuration of the sensor surfaces. To this end, inorganic inve… Show more
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