Enhanced Epilepsy Surveillance and Awareness in the Age of Zika

Pastula, Daniel M.; Yeargin‐Allsopp, Marshalyn; Kobau, Rosemarie

doi:10.1001/jamaneurol.2017.0215

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…96 -98 More data are needed to better understand the consequences and impacts of Zika-associated disabilities. 96 Multidisciplinary systems of support engaging parents, health care providers, educational resources, and others within a community are needed to address factors that affect the quality of life for surviving children and their families. 97, 99, 100 Improved public awareness of the possible profound and lifelong effects of ZIKV infection during pregnancy (ie, more than just microcephaly) is needed to garner support for the necessary programs and policies that can benefit infants who are affected by Zika as well as the larger population of children with special health care needs.…”

Section: Discussionmentioning

confidence: 99%

Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection

Linden²,

et al. 2018

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Initial reports of congenital Zika virus (ZIKV) infection focused on microcephaly at birth with severe brain anomalies; the phenotype has broadened to include microcephaly that develops after birth and neurodevelopmental sequelae. In this narrative review, we summarize medical literature describing motor abnormalities and epilepsy in infants with evidence of congenital ZIKV infection and provide information on the impact of these conditions. Specific scenarios are used to illustrate the complex clinical course in infants with abnormalities that are consistent with congenital Zika syndrome. A search of the English-language medical literature was done to identify motor abnormalities and epilepsy in infants with evidence of congenital ZIKV infection by using Medline and PubMed, Embase, Scientific Electronic Library Online, Scopus, the OpenGrey Repository, and the Grey Literature Report in Public Health. Search terms included "Zika" only and "Zika" in combination with any of the following terms: "epilepsy," "seizure," "motor," and "cerebral palsy." Clinical features of motor abnormalities and epilepsy in these children were reviewed. Thirty-six publications were identified; 8 were selected for further review. Among infants with clinical findings that are consistent with congenital Zika syndrome, 54% had epilepsy and 100% had motor abnormalities. In these infants, impairments that are consistent with diagnoses of cerebral palsy and epilepsy occur frequently. Pyramidal and extrapyramidal motor abnormalities were notable for their early development and co-occurrence. Prompt identification of potential disabilities enables early intervention to improve the quality of life for affected children. Long-term studies of developmental outcomes and interventions in children with congenital ZIKV infection are needed.

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Section: Discussionmentioning

confidence: 99%

Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection

Linden²,

et al. 2018

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“…Although not a genetic cause of epilepsy, congenital ZIKV virus infection is known to cause microcephaly and severe brain abnormalities in infants, [214][215][216] and infected subjects also have a high risk of epilepsy. 217 Recent studies using human brain organoids to model ZIKV infection have demonstrated that it induces the death of neural progenitor cells and impairs organoid formation, providing certain mechanistic insights into disease pathogenesis. 29,218,219 However, none of these studies recapitulated the key developmental features of the human cortex such as surface area and folding.…”

Section: Zikv Infectionmentioning

confidence: 99%

Modeling genetic epilepsies in a dish

Niu

Parent

2019

Developmental Dynamics

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Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, provide a powerful platform for mechanistic studies of disorders of neurodevelopment and neural networks. hPSC models of autism, epilepsy, and other neurological disorders are also advancing the path toward designing and testing precision therapies. The field is evolving rapidly with the addition of genome-editing approaches, expanding protocols for the two-dimensional (2D) differentiation of different neuronal subtypes, and three-dimensional (3D) human brain organoid cultures. However, the application of these techniques to study complex neurological disorders, including the epilepsies, remains a challenge. Here, we review previous work using both 2D and 3D hPSC models of genetic epilepsies, as well as recent advances in the field. We also describe new strategies for applying these technologies to disease modeling of genetic epilepsies, and discuss current challenges and future directions. K E Y W O R D S brain organoid, epilepsy, genome editing, human pluripotent stem cells, neurological disorder, seizure disorder

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Effects on Adults

Berube

2023

Risk, Systems and Decisions

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Enhanced Epilepsy Surveillance and Awareness in the Age of Zika

Cited by 5 publications

References 5 publications

Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection

Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection

Modeling genetic epilepsies in a dish

Effects on Adults

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