Enhanced endothelin‐1‐induced contractions in mesenteric arteries from rats with congestive heart failure: role of ET<sub>B</sub> receptors

Bergdahl, Anders; Valdemarsson, Stig; Adner, Mikael; Sun, Xingshu; Hedner, T.; Edvinsson, Lars

doi:10.1016/s1388-9842(01)00138-6

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…Nonetheless, the dilatory role of ET B receptors is not significant in isolated human coronary arterial rings (Pierre & Davenport, 1998). Further data even suggest that in pathology, stimulation of endothelial ET B receptors might be ET-1 Pharmacology detrimental by inducing effects such as cell adhesion or contraction (Bergdahl et al, 2001;Schneider et al, 2007;Sen et al, 2009). This suggests that in pathology the vasodilating effect of endothelial ET B receptor stimulation may be lost.…”

Section: The Endothelium-dependent Responses To Et-1mentioning

confidence: 98%

The Cardiovascular Physiology and Pharmacology of Endothelin-1

Thorin

Clozel

2010

Advances in Pharmacology

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One year after the discovery in 1980 that the endothelium was obligatory for acetylcholine to relax isolated arteries, it was clearly shown that the endothelium could also promote contraction. In 1988, Dr Yanagisawa's group identified endothelin-1 (ET-1) as the first endothelium-derived contracting factor. The circulating levels of this short (21 amino acids) peptide were quickly determined in humans and it was reported that in most cardiovascular diseases, circulating levels of ET-1 were increased and ET-1 was then recognized as a likely mediator of pathological vasoconstriction in human. The discovery of two receptor subtypes in 1990, ET(A) and ET(B), permitted optimization of bosentan, which entered clinical development in 1993, and was offered to patients with pulmonary arterial hypertension in 2001. In this report, we discuss the physiological and pathophysiological role of endothelium-derived ET-1, the pharmacology of its two receptors, focusing on the regulation of the vascular tone and as much as possible in humans. The coronary bed will be used as a running example, but references to the pulmonary, cerebral, and renal circulation will also be made. Many of the cardiovascular complications associated with aging and cardiovascular risk factors are initially attributable, at least in part, to endothelial dysfunction, particularly dysregulation of the vascular function associated with an imbalance in the close interdependence of NO and ET-1, in which the implication of the ET(B) receptor may be central.

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Section: The Endothelium-dependent Responses To Et-1mentioning

confidence: 98%

The Cardiovascular Physiology and Pharmacology of Endothelin-1

Thorin

Clozel

2010

Advances in Pharmacology

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“…There is general agreement that in HF, low cardiac output (11,12,16,17) and increased synthesis of vasoconstrictor agents (13,16,17) may contribute to peripheral hemodynamic abnormalities (18). Experimental evidence (19,20) suggests that altered perfusion can stimulate the release of prooxidant superoxide from vascular tissues, impair vasodilatation, and enhance production of peroxynitrite with consequent vascular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Mesenteric Vascular Dysfunction After Cardiopulmonary Bypass With Cardiac Arrest Is Aggravated by Coexistent Heart Failure

Andrási

Bielik

Blázovics

et al. 2005

Shock

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Although patients suffering from heart failure (HF) have an increased incidence of nonocclusive mesenteric ischemia after opened heart surgery, the impact of cardiopulmonary bypass with cardiac arrest (CPB) on mesenteric vascular circulation in such situation remains unexplored. Therefore, the present study investigates the effects of CPB on mesenteric vascular reactivity, regional metabolism, and oxidative stress in an experimental model of HF. Volume-overload HF was induced in six dogs by bilateral femoral arteriovenous fistula. Six sham-operated dogs were used as controls. Eight weeks later, the short-term effects of 90 min of CPB were assessed in vivo during acute experiments. The significant increase in left ventricular end-diastolic volume in HF animals did not influence the vasodilator response of the superior mesenteric artery to acetylcholine (ACH) and nitroprusside (SNP) under baseline conditions. However, reduced mesenteric oxygen delivery, increased oxygen extraction, and lactate release were found during CPB in the HF group. In addition, an increased free radical production was assessed in the HF group during (89 +/- 23 x 10 relative light units [RLU]) and after CPB (93 +/- 15 x 10 RLU) compared with controls (45 +/- 15 and 49 +/- 7 x 10 RLU, respectively). Finally, 90 min of CPB led to a more pronounced decrease of ACH- (-22% +/- 5% vs. -42% +/- 9%, P < 0.05) and SNP- (-14% +/- 4% vs. -50% +/- 7%, P < 0.002) induced mesenteric vasodilations in the HF group compared with controls. We conclude that coexistent HF significantly enhances the pathological effects of CPB on the mesenteric vascular circulation by additionally altering endothelial and smooth muscle vascular function consequent to augmented oxidative stress.

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“…It has been revealed that the vascular ET B and ET A receptors are involved in the atherosclerotic process [2]. Upregulation of the ET-1 and ET B receptor is found in human atherosclerotic lesions [3,4,5] and experimental models of heart failure [6,7]. Increased ET B receptor-mediated responses have been demonstrated in human atherosclerotic arteries [3,4].…”

Section: Introductionmentioning

confidence: 99%

DMSO-Soluble Cigarette Smoke Particles Alter the Expression of Endothelin B Receptor in Rat Coronary Artery

Huang

Zhang²,

He³

et al. 2013

J Vasc Res

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In coronary artery diseases, cigarette smoking is a risk factor and the endothelin system plays a key role in the pathogenesis. This study was to examine if dimethylsulfoxide-soluble smoke particles (DSP) upregulate endothelin type-B (ET_B) receptors in the coronary artery and investigate the mechanism. The isolated rat coronary arteries were organ-cultured for 24 h. The contractile response of the coronary artery was recorded by myograph. The mRNA and protein expression of the ET_B receptors was studied using quantitative real-time PCR and immunohistochemistry. Results showed that the ET_B receptor agonist, sarafotoxin 6c, induced a weak contraction in the fresh coronary artery. After culture, the contraction curve mediated by ET_B receptor was shifted towards the left with an increased E_max of 152 ± 12%. DSP of 0.2 and 0.4 µl/ml shifted the concentration-contractile curves towards the left with further increased E_max of 270 ± 26 and 280 ± 29%, respectively. The culture increased ET_B receptor mRNA and protein levels from fresh arteries, which was further enhanced by DSP. PD98059 (ERK1/2 inhibitor), wedelolactone (NF-κB inhibitor), actinomycin D or cycloheximide significantly inhibited the DSP-enhanced contraction and expression of mRNA and protein of the ET_B receptor. However, SB203580 (p38 inhibitor) further increased DSP-enhanced contraction and protein expression of the ET_B receptor. The results indicate that DSP upregulates ET_B receptors in rat coronary artery via ERK1/2 and the NF-κB pathway.

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Enhanced endothelin‐1‐induced contractions in mesenteric arteries from rats with congestive heart failure: role of ET_B receptors

Cited by 8 publications

References 24 publications

The Cardiovascular Physiology and Pharmacology of Endothelin-1

The Cardiovascular Physiology and Pharmacology of Endothelin-1

Mesenteric Vascular Dysfunction After Cardiopulmonary Bypass With Cardiac Arrest Is Aggravated by Coexistent Heart Failure

DMSO-Soluble Cigarette Smoke Particles Alter the Expression of Endothelin B Receptor in Rat Coronary Artery

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Enhanced endothelin‐1‐induced contractions in mesenteric arteries from rats with congestive heart failure: role of ETB receptors

Cited by 8 publications

References 24 publications

The Cardiovascular Physiology and Pharmacology of Endothelin-1

The Cardiovascular Physiology and Pharmacology of Endothelin-1

Mesenteric Vascular Dysfunction After Cardiopulmonary Bypass With Cardiac Arrest Is Aggravated by Coexistent Heart Failure

DMSO-Soluble Cigarette Smoke Particles Alter the Expression of Endothelin B Receptor in Rat Coronary Artery

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Enhanced endothelin‐1‐induced contractions in mesenteric arteries from rats with congestive heart failure: role of ET_B receptors