Enhanced electrochemical response of a modified glassy carbon electrode by poly(2-vinlypyridine-<i>b</i>-methyl methacrylate) conjugated gold nanoparticles for detection of nicotine

Rahim, Sana; Rauf, Asma; Rauf, Saba; Shah, Muhammad Raza; Malik, Muhammad Imran

doi:10.1039/c8ra06857g

Cited by 18 publications

(7 citation statements)

References 45 publications

(53 reference statements)

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“…Nicotine(S)3-(1-methylpyrrolidin-2-yl) pyridine (NIC) is one of the fatal toxicities of purine alkaloids which represents about 2–8% of the tobacco plants (Nicotiana genus such as N. Tabacum, N. Rustica, and N. Glauca) [ 1 , 2 , 3 , 4 , 5 ]. It is an oily, hygroscopic, colorless pale yellow liquid that quickly dissolves in water at room temperature [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical Sensor for Detection of Nicotine in Tobacco Products Based on Graphene Oxide Nanosheets Conjugated with (1,2-Naphthoquinone-4-Sulphonic Acid) Modified Glassy Carbon Electrode

et al. 2022

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A simple electrochemical sensor for nicotine (NIC) detection was performed. The sensor based on a glassy carbon electrode (GCE) was modified by (1,2-naphthoquinone-4-sulphonic acid)(Nq) decorated by graphene oxide (GO) nanocomposite. The synthesized (GO) nanosheets were characterized using X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscope (SEM), transmission electron microscope (TEM), FT-IR, and UV-Visible Spectroscopy. The insertion of Nq with GO nanosheets on the surface of GCE displayed high electrocatalytic activity towards NIC compared to the bare GCE. NIC determination was performed under the optimum conditions using 0.10 M of Na2SO4 as a supporting electrolyte with pH 8.0 at a scan rate of 100 mV/s using both cyclic voltammetry (CV) and differential pulse voltammetry (DPV). This electrochemical sensor showed an excellent result for NIC detection. The oxidation peak current increased linearly with a 6.5–245 µM of NIC with R2 = 0.9999. The limit of detection was 12.7 nM. The fabricated electrode provided satisfactory stability, reproducibility, and selectivity for NIC oxidation. The reliable GO/Nq/GCE sensor was successfully applied for detecting NIC in the tobacco product and a urine sample.

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Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical Sensor for Detection of Nicotine in Tobacco Products Based on Graphene Oxide Nanosheets Conjugated with (1,2-Naphthoquinone-4-Sulphonic Acid) Modified Glassy Carbon Electrode

et al. 2022

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“…The stabilized AuNPs have exciting surface plasmonic properties and found applications in various research fields such as sensors [23], drug delivery [24], biomedical imaging [25], cancer treatment [26] and in diagnosis and therapy of several other diseases [27]. AuNPs have been employed for the colorimetric detection of biological and chemical compounds due to their large surface area and specific distance-dependent optical properties [12,22,[28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

“…In this context, our group have reported numerous chemo-sensors based on metal nanoparticles by using different stabilizing agents for their specific and selective response to different analytes such as insecticides, drugs, metal ions, etc. [22,29,36,38,39]. Among numerous stabilizing agents for NPs, polyethylene glycol (PEG) has been extensively used due to its high biocompatibility, excellent water solubility and non-biofouling characteristics [40].…”

Section: Introductionmentioning

confidence: 99%

Colorimetric sensing of cephradine through polypropylene glycol functionalized gold nanoparticles

et al. 2021

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The development of metal nanoparticle-based facile colorimetric assays for drugs and insecticides is an emerging area of current scientific research. In the present work, polypropylene glycol was used for stabilization of gold nanoparticles (AuNPs) in a simple one-pot two-phase process and subsequently employed it for the specific detection of cephradine (CPH). The characterization of the prepared PPG-AuNPs was conducted through various analytical techniques such as UV-visible spectrophotometry, Fourier transform infrared spectroscopy, atomic force microscopy (AFM), zeta potential and zetasizer techniques. As the major target of the study, the stabilized PPG-AuNPs were employed for colorimetric detection of CPH and other drugs. Typical wine-red colour of PPG-AuNPs disappeared immediately and surface plasmon resonance band quenched by addition of CPH in the presence of several other interferents (drugs and salts) and in real samples. PPG-AuNPs permitted efficient, selective, reliable and rapid determination in a concentration range of 0.01–120 mM with a detection limit (LoD) of 11.0 mM. The developed sensor has the potential to be used for fast scanning of pharmaceutical formulations for quantification of CPH at production facilities.

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“…The intensity of SPR band enhanced with an increase in the concentration of salt (Figure S6‐Supplementary Material), suggesting that TU3‐AgNPs are more stable at higher salt concentrations. An increase in the concentration of Cl − ions (that may act as ligands) render increased stabilization of AgNPs in solution . A slight blue shift in SPR band of salt treated TU3 ‐AgNPs might be attributed to the production of smaller sized nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

“…In this study, the nanoparticles were capped by a specially designated thiourea‐based molecule, N‐((4‘‐methoxy‐2‘‐nitrophenyl) carbamothioyl) dodecanamide (TU 3 ) that contains lone pair of electrons on nitrogen, sulfur and oxygen atoms. The presence of lone pairs protects the nanoparticles from agglomeration owing to their tendency to coordinate with metal ions …”

Section: Introductionmentioning

confidence: 99%

A Novel and Efficient Colorimetric Assay for Quantitative Determination of Amlodipine in Environmental, Biological and Pharmaceutical Samples

et al. 2019

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Development of facile, on-spot, robust, and efficient optical nanosensors for drugs and pesticides is one of the active research area. In this study, a nanosensor based on fairly stable silver nanoparticles (AgNPs) conjugated with specially designed thiourea (TU)-based molecule, N-((4'-methoxy-2'-nitrophenyl) carbamothioyl) dodecanamide (TU3), was prepared using one pot protocol and characterized by Ultraviolet (UV)-Visible spectroscopy, dynamic light scattering (DLS), fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM). The TU3 conjugated AgNPs (TU3-AgNPs) were found to be selective spectrophotometric sensor for an antimicrobial drug, amlodipine (Ad), among the pool of different drugs. TU3-AgNPs based nanosensor allows for the rapid quantitative assay having a detection limit of 0.3 μM in an analytical range of 0.1-100 μM. The proposed sensor is specific in presence of number of other interfering drugs and other matrix. Upto the best of our literature survey, this is first ever colorimetric sensor for quantification of amlodipine in complex matrix. The specificity of the sensor allows for quantitative detection of amlodipine in environmental, biological and pharmaceutical samples.

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Enhanced electrochemical response of a modified glassy carbon electrode by poly(2-vinlypyridine-b-methyl methacrylate) conjugated gold nanoparticles for detection of nicotine

Abstract: Poly(2-vinylpyridine-b-methylmethacrylate) coated gold nanoparticles [P(2VP-MMA)-AuNPs] are employed for enhancement of electrochemical response of glassy carbon electrode for nicotine.

Cited by 18 publications

References 45 publications

A Novel Electrochemical Sensor for Detection of Nicotine in Tobacco Products Based on Graphene Oxide Nanosheets Conjugated with (1,2-Naphthoquinone-4-Sulphonic Acid) Modified Glassy Carbon Electrode

A Novel Electrochemical Sensor for Detection of Nicotine in Tobacco Products Based on Graphene Oxide Nanosheets Conjugated with (1,2-Naphthoquinone-4-Sulphonic Acid) Modified Glassy Carbon Electrode

Colorimetric sensing of cephradine through polypropylene glycol functionalized gold nanoparticles

A Novel and Efficient Colorimetric Assay for Quantitative Determination of Amlodipine in Environmental, Biological and Pharmaceutical Samples

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