Enhanced efficacy of diclofenac sodium-loaded lipogelosome formulation in intra-articular treatment of rheumatoid arthritis

Türker, Selcan; Erdoğan, Suna; Özer, Yekta A.; Bilgili, Hasan; Deveci, Salih

doi:10.1080/10611860701725191

Cited by 32 publications

(11 citation statements)

References 19 publications

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“…Diclofenac sodium (DFN) is widely used in RA therapy by oral administration. However, they have certain limitations like shorter half life and mucosal irritation (Turker et al 2008). Topical administration reduces the oral side effects, but they suffer from limited permeation of DFN.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art

Rahman

Kumar

Beg

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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Inflammatory diseases are considered to be highly dreadful ones responsible for higher mortality in the developed countries. This includes cancer, psoriasis, rheumatoid arthritis, and inflammatory bowel disease. The tremendous strides in the area of drug development to find newer molecules like non-steroidal and steroidal agents and immunosuppressant agents delivered by conventional formulation. These therapy have enhances the life expectancy of patient, but it provide the therapeutic benefits only to a limited extent. Recent advancement in liposomes based nanomedicines has led to the possibility of improves the efficacy and safety of the pharmacotherapy of inflammatory disorders. Of late, liposomes have been highly explored as one of the promising systems for delivering numerous anti-inflammatory drugs for attaining enhanced therapeutic outcomes. Over the conventional carriers, liposomal systems have numerous drug delivery merits including advantages in both passive and active targeting of drug molecules to the inflammatory lesions. The current review article, therefore, endeavors to provide a bird's eye view account on the success of liposome-based therapeutic systems in the management of dreadful inflammatory disorders along with updated knowledge to pharmaceutical scientists in the field.

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Section: Rheumatoid Arthritismentioning

confidence: 99%

Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art

Rahman

Kumar

Beg

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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“…This kind of drug delivery system was able to send the drug directly to the target area in a localized manner, avoiding the physiological barriers of transportation and changing its distribution in the human body [3], which can effectively reduce the dose of drug hence minimize the toxicity. Therefore, this delivery mode attracted more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration

Chen

Liu

Liú

et al. 2012

Journal of Controlled Release

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“…Retention of drugs in the joints using controlled release delivery system offers an exciting option for intra‐articular drug delivery. Researchers thus have tried to encapsulate the drugs into different drug delivery systems such as liposomes, nanoparticles, and microparticles 5–10. Although more promising than drug suspensions, these systems also faced a major drawback of short retention in the joint due to synovial capillary and lymphatic drainage, which takes place within a few days after injection 11, 12.…”

Section: Introductionmentioning

confidence: 99%

Injectable thermosensitive hydrogels for intra‐articular delivery of methotrexate

Bo-long

Song

2011

J of Applied Polymer Sci

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Intra-articular drug delivery is the preferred approach for targeting pharmacologic treatment directly at the joints to reduce undesirable side effects associated with systemic drug delivery. In this study, a controlled delivery system of methotrexate (MTX) based on injectable thermosensitive poly(e-caprolactone)-poly (ethylene glycol)-poly(e-caprolactone) (PCL-PEG-PCL, PEP) hydrogels was developed for the intra-articular drug delivery. The thermosensitive PEP copolymers were prepared by ring-opening polymerization. The synthesized PEP copolymers were characterized for their structure, composition, and the sol-to-gel transition. The in vitro MTX release from the PEP hydrogels was studied. MTX plasma concentration following intra-articular injection into healthy rats was determined by HPLC. Biocompatibility was confirmed by histology analysis after the intra-articular injection. The synthesized PEP copolymers aqueous solutions formed in situ gel rapidly after the injection. PEP hydrogels showed the ability to control the release of incorporated MTX. Following intra-articular injection, the PEP hydrogels decreased the clearance rate of MTX in the joint cavity. The maximum plasma concentrations of MTX in rats injected with free MTX were threefold higher than that of the groups injected with MTX hydrogels. These results suggest that the intra-articular delivery of the PEP hydrogels may be a viable strategy for the controlled release of drugs for treating arthritis diseases.

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Enhanced efficacy of diclofenac sodium-loaded lipogelosome formulation in intra-articular treatment of rheumatoid arthritis

Cited by 32 publications

References 19 publications

Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art

Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art

Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration

Injectable thermosensitive hydrogels for intra‐articular delivery of methotrexate

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