Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform

Arno, Maria C.; Simpson, Joshua D.; Blackman, Lewis D.; Brannigan, Ruairí P.; Thurecht, Kristofer J.; Dove, Andrew P.

doi:10.1039/d2bm01626e

Cited by 2 publications

(2 citation statements)

References 72 publications

(92 reference statements)

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“…Such a problem is closely similar to that of a complex SI requiring precise spatial assistance, as the IG assistance discussed in the last section. This implanted therapy will be MI-NI-IG-RDD [42][43][44][45][46][47][48][49][50]. The implant structure may be of non-biodegradable material but must be MRI-compatible when using such imaging techniques [95,96].…”

Section: Implantable Drug Delivery Schemesmentioning

confidence: 99%

“…Recent work considering RDD has been reported in the literature; see e.g., [42][43][44][45][46][47][48][49][50]. These regard USI-guided DD enhancement, microbubble-mediated USI DD, microneedle patches for DD, DD to cancer cells, spatial, temporal, and dose control of DD, nanoparticlesbased strategies to improve the delivery of therapeutic RNA in precision oncology, nanoparticle-based delivery systems in pancreatic cancer, and nano-drug delivery system for cancer.…”

Section: Introductionmentioning

confidence: 99%

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Image-Guided Surgical and Pharmacotherapeutic Routines as Part of Diligent Medical Treatment

Razek

2023

Applied Sciences

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This contribution is part of the objective of diligent universal care that ensures the well-being of a patient. It aims to analyze and propose enriched image-guided procedures for surgical interventions and restricted delivery of implanted drugs in minimally invasive and non-ionizing circumstances. This analysis is supported by a literature review conducted in two ways. The first aims to illustrate the importance of recent research and applications involved in different topics of the subject; this is mainly the case for the introduction’s literature. The second concerns the literature dedicated to having more detailed information in context; this mainly concerns the citations in the different sections of the article. The universal goals of medical treatments are intended to involve the well-being of the patient and allow medical personnel to test new therapies and carry out therapeutic training without risk to the patient. First, the various functionalities involved in these procedures and the concerns of the magnetic resonance imaging technique (MRI) and ultrasound imaging technique (USI), recent contributions to the subject are reviewed. Second, the intervention procedures guided by the image and the implemented actions are analyzed. Third, the components of the fields involved in MRI are examined. Fourth, the MRI control of the treatments, its performance and its compliance are analyzed. Compatibility with MRI via electromagnetic compatibility (EMC) is conferred and demonstrated for an actuation example. Fifth, the extension of the concepts mentioned in the article, in the context of patient comfort and the training of medical staff is proposed. The main contribution of this article is the identification of the different strategic aids needed in healthcare related to image-assisted robotics, non-ionized, minimally invasive and locally restrictive means. Furthermore, it highlights the benefits of using phantoms based on real biological properties of the body, digital twins under human control, artificial intelligence tools and augmented reality-assisted robotics.

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Section: Implantable Drug Delivery Schemesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Image-Guided Surgical and Pharmacotherapeutic Routines as Part of Diligent Medical Treatment

Razek

2023

Applied Sciences

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pH-Sensitive Polymer–Drug Conjugates

Gillies

2024

Chem. Mater.

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Polymer−drug conjugates (PDCs) were introduced with the goal of improving the properties of drug molecules, such as their solubility, blood circulation time, and tissue targeting. Since the first examples dating back decades, substantial progress has been made in the design and implementation of linkages that enable the selective release of drugs in response to physiological stimuli associated with various pathologies. Among these stimuli, a change in pH from neutral to mildly acidic has been one of the most widely exploited. This perspective will discuss the advantages and limitations of different linker strategies and their applications in the development of PDCs to treat cancer, inflammation, and bacterial infection. These materials range from soluble linear and branched polymer systems to nanoparticles, hydrogels, and coatings. Both an historical perspective and recent developments will be presented. Finally, some ongoing challenges will be discussed, along with opportunities for future work.

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Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform

Abstract: Polymer-drug conjugates are widely investigated to enhance the selectivity of therapeutic drugs to cancer cells, as well as increase circulation lifetime and solubility of poorly soluble drugs. In order to...

Cited by 2 publications

References 72 publications

Image-Guided Surgical and Pharmacotherapeutic Routines as Part of Diligent Medical Treatment

Image-Guided Surgical and Pharmacotherapeutic Routines as Part of Diligent Medical Treatment

pH-Sensitive Polymer–Drug Conjugates

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