Enhanced Donor Antigen Presentation by B Cells Predicts Acute Cellular Rejection and Late Outcomes After Transplantation
Chethan Ashokkumar,
Mylarappa Ningappa,
Vikram Raghu
et al.
Abstract:Background.
Enhanced B-cell presentation of donor alloantigen relative to presentation of HLA-mismatched reference alloantigen is associated with acute cellular rejection (ACR), when expressed as a ratio called the antigen presenting index (API) in an exploratory cohort of liver and intestine transplant (LT and IT) recipients.
Methods.
To test clinical performance, we measured the API using the previously described 6-h assay in 84 LT and 54 IT recipient… Show more
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