Enhanced DNA repair, immune function and reduced toxicity of C-MED-100™, a novel aqueous extract from Uncaria tomentosa

Sheng, Yuchen; Bryngelsson, Carl; Pero, Ronald W.

doi:10.1016/s0378-8741(99)00070-7

Cited by 89 publications

(128 citation statements)

References 35 publications

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“…38 Moreover, elevated leukocyte numbers were noted in humans, mice, and rats receiving repeat doses of the extract. 3,113 Enhanced leukocyte counts correlated with prolonged lymphocyte survival, thus providing a potential mechanistic basis for the immune enhancing properties of the extract. 113 Prolonged cell survival has been linked to enhanced DNA repair.…”

Section: Introductionmentioning

confidence: 88%

“…The lactone 14 was then allowed to to react with N-propyl amine with acetic acid at 85C, and then resulting amide 15. The synthesis of compound 22 was carried out using sinapic acid 21 treated with Ac 2 O in pyridine, DMAP, at room temperature; Compounds 15 and 22 were mixed in CH 2 Cl 2 , treated with DMAP, DIC, at room temperature, and then resulting 3-(4-Acetoxy-3,5-dimethoxy-phenyl)-acrylic acid 6-hydroxy-2,2-dimethyl-6-propylcarbamoyl-hexahydro-benzo [1,3]…”

Section: 93mentioning

confidence: 99%

“…Recently, quinic acid (QA) and QA esters have been identified as active anti-inflammatory ingredients in hot water extracts of the herbal Uncaria tomentosa or Cat's claw (e.g., C-MED-100  ), 1,2 and shown to enhance immune cell response and DNA repair in humans. [3][4][5] This chapter will give an overview on the most recent studies on QA and its derivatives in the following fields, such as: biosynthesis and catabolism in nature, synthesis, biological activities, mechanisms of anti-inflammatory activity, etc.…”

Section: Chapter 1 Introductionmentioning

confidence: 99%

“…113 Prolonged cell survival has been linked to enhanced DNA repair. [3][4][5] Recently, quinic acid (QA) esters have been identified as biologically active components in the extract. 1 The mechanism by which QA and its esters exert their anti-inflammatory activity is unclear, but appears to be related to inhibition of the pro-inflammatory transcription factor nuclear factor kappa B (NF-B).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, QA has been identified as an active inflammatory ingredient in hot water extracts of the herbal Cat's claw (e.g., C-MED-100  ), and shown to enhance immune cell response and DNA repair in humans. [3][4][5] Unfortunately, QA is utilized by gastrointestinal bacteria as a carbon source for aromatic acid synthesis. Consequently, only a small fraction of QA is absorbed after oral administration of QA.…”

Section: Introductionmentioning

confidence: 99%

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Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents

Zeng¹

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Section: Introductionmentioning

confidence: 88%

Section: 93mentioning

confidence: 99%

Section: Chapter 1 Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents

Zeng¹

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Quinic Acid Derivative KZ‐41 Exhibits Radiomitigating Activity in Preclinical Models of Radiation Injury

Thompson

Zeng

Wilson

et al. 2013

Drug Development Research

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Acute radiation syndrome is induced when a significant portion of the body receives high-dose, as well as high-dose rate, radiation. We have previously identified a quinic acid-based derivative, KZ-41, that protects from radiation injury. Further preclinical efficacy studies were conducted to determine the radiomitigating activity of KZ-41. C57BL/6 mice received total body irradiation (TBI-LD₈₀/₃₀, ¹³⁷Cs; ∼2 min) followed by either normal saline or KZ-41 (100 mg/kg sc ∼26 h post-TBI). KZ-41 increased 30-day survival by approximately 45% compared with vehicle controls (P < 0.05). To further investigate the potential radiomodulating mechanisms of KZ-41, we developed a combined radiation and vascular injury model. C57BL/6 mice surgically fixed with dorsal windows for dermal vasculature imaging received either sham or TBI (¹³⁷Cs; 6 Gray). Postcapillary venule injury was induced (24, 48, 72, and 96 h post-TBI) followed by imaging at 5 min and 24 h to assess clot formation and blood flow. Impairment in flow (P < 0.05) and clot formation (P < 0.05) were observed as early as 48 and 72 h, respectively. Thus, vascular injury 72 h post-TBI was used to evaluate intervention (KZ-41; 100 mg/kg i.p. at 12, 36, and 60 h post-TBI) on radiation-induced changes in both flow and clot formation. KZ-41, although not improving flow, increased clot formation (P < 0.05). Platelet counts were lower in both irradiated groups compared with sham controls (P < 0.05). In summary, KZ-41 exerts radiomitigating activity in lethally irradiated mice. Imaging results suggest KZ-41 exerts radiomitigating activity through mechanisms involving promotion of initial clot formation and vascular flow restoration. The imaging model described herein is useful for further examination of radiation-induced vascular injury repair mechanisms.

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Advances in chemistry and bioactivity of the genus Uncaria

Laus¹

2004

Phytotherapy Research

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The alkaloids of the pantropical genus Uncaria (Rubiaceae) were reviewed extensively by Phillipson et al. in (1978) Since then a host of papers with new results has been published. The compounds discovered are from three major groups: (1) alkaloids; (2) terpenoids; and (3) flavonoids. Some highly unusual structures have been reported. Although there are at least 35 species of Uncaria known, recent research focussed on a relatively small number of species. During recent years bioactivity of extracts and pure compounds isolated from Uncaria species have been increasingly investigated. These include anticonvulsive, antiinflammatory, antimutagenic, antioxidant, cytoprotective, hypotensive, and immunoregulatory effects. The literature since 1978 is reviewed and 133 references are given.

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Enhanced DNA repair, immune function and reduced toxicity of C-MED-100™, a novel aqueous extract from Uncaria tomentosa

Cited by 89 publications

References 35 publications

Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents

Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents

Quinic Acid Derivative KZ‐41 Exhibits Radiomitigating Activity in Preclinical Models of Radiation Injury

Advances in chemistry and bioactivity of the genus Uncaria

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