Enhanced dissolution and bioavailability of grapefruit flavonoid Naringenin by solid dispersion utilizing fourth generation carrier

Abstract

Based on these results, it was concluded that solid dispersion technique markedly enhances the in vitro drug release and in vivo behavior of the grapefruit flavonoid NRG.

Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

“…Zhang et al [94] aimed to improve the oral absorption of baicalin, which has low solubility and poor permeability, by using a micellar formulation comprised of the carriers Pluronic P123 copolymer and sodium taurocholate. Sustained release profile of baicalin-loaded mixed micelles, in in vitro drug release experiment, held in several pH conditions, showed 14% drug released after 2 h in gastric conditions and 54% release within 48 h in intestinal conditions, compared to 34% and 79% release [105], nanoparticles [106][107][108][109][110], phytosome [111], nanoliposome [112], mixed micelles [113,114], SNEDDS [115,116], nanocarrier [117,118], nanoemulsion [119], nanosuspension [ Mixed micelles [129,130], nanoparticles [131,132], solid dispersion [133,134] , SNEDDS [135] , SMEDDS [136], lipid carrier [137], copolymeric micelles [138], exosomes [139] Naringenin DENV, HCV SNEDDS [140], solid dispersion [141], nanoparticles [142,143] , liposome [144], nanosuspension [145,146] In vitro uptake studies, carried out with a caco-2 cell line, determined the absorption of baicalin within the mixed micelles and verified their internalization ability. Baicalin-loaded ST-P123-MMs formulation achieved high oral bioavailability (Fig.…”

Mefenamic acid taste-masked oral disintegrating tablets with enhanced solubility via molecular interaction produced by hot melt extrusion technology

“…Various strategies for improving solubility of poorly water soluble drugs have been developed, such as micronization, chemical modification, pH adjustment, solid dispersion formation, complexation, co-solvency, micellar solubilization, hydrotropy etc [14]. Amorphous solid dispersion formulation is a technique that leads to the conversion of the crystalline lattice to the amorphous phase and disperses the drug molecules in a suitable carrier in order to enhance the solubility of the drug [15]. High drug load in the drug delivery system, especially in solid dispersion systems, is crucial when high dosing is required.…”

Enhancement of the Solubility and the Dissolution Rate of Tamoxifen Citrate Solid Dispersion Using Soluplus by Solvent Evaporation Technique

“…FTIR was conducted to look into any alteration of the crystalline type of TMX after solid dispersion process. A sample of about 1 mg of the drug was grounded then mixed with potassium bromide and compressed through a manual press to form a thin disc and analyzed using FTIR spectroscopy in a range from 4000 to 400/cm [12].…”

“…Diffraction model of TMX plain powder, Soluplus plain powder, and the selected solid dispersion formulation were attempted to determine the degree of crystallinity using (Shimadzu, Japan) X-ray diffractometer by utilizing Cu K α radiation with a nickel filter, a voltage of 40 kV, and a current of 25 mA. The samples were analyzed in a range from 5°C to 50°C [12].…”