Enhanced diffusometric immunosensing with grafted gold nanoparticles for detection of diabetic retinopathy biomarker tumor necrosis factor-α

Chuang, Huey-Ru; Chen, Yu‐Ju; Cheng, Hsu-Chih

doi:10.1016/j.bios.2017.10.002

Cited by 33 publications

(25 citation statements)

References 24 publications

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“…Over the last two decades, Au NPs have been mainly used as biosensors and as contrast agents in X-ray imaging and computed tomography (Kobayashi et al 2016 ), being applied in biological and biomedical research, especially in cancer diagnosis (Chuang et al 2018 ; Kim et al 2018 ; Sugumaran et al 2018 ) and therapy (Khandanlou et al 2018 ; Zhu et al 2018 ), biosensing (Baetsen-Young et al 2018 ; Chen et al 2009 ), virus detection, and regulation of cell function (Bodelon et al 2017 ; Giljohann et al 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles

et al. 2018

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Hydrophilic and homogeneous sub-10 nm blue light-emitting gold nanoparticles (NPs) functionalized with different capping agents have been prepared by simple chemical routes. Structure, average, size, and surface characteristics of these NPs have been widely studied, and the stability of colloidal NP solutions at different pH values has been evaluated. Au NPs show blue PL emission, particularly in the GSH capped NPs, in which the thiol-metal core transference transitions considerably enhance the fluorescent emission. The influence of capping agent and NP size on cytotoxicity and on the fluorescent emission are analyzed and discussed in order to obtain Au NPs with suitable features for biomedical applications. Cytotoxicity of different types of gold NPs has been determined using NPs at high concentrations in both tumor cell lines and primary cells. All NPs used show high biocompatibility with low cytotoxicity even at high concentration, while Au-GSH NPs decrease viability and proliferation of both a tumor cell line and primary lymphocytes.Electronic supplementary materialThe online version of this article (10.1007/s11051-018-4406-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles

et al. 2018

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“…A lot of proliferative neovascularization diseases, especially happens at the posterior part of the eye, could lead to serious ocular problems even the blindness (Witmer et al., 2003 ), such as wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy of prematurity (Jager et al., 2008 ; Chuang et al., 2018 ; Xu et al., 2018 ). The critical mechanism of these diseases is the aberrant formation of new blood vessels in the eyes.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid modified MPEG-b-PAE block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein

Liu

Chen

et al. 2018

Drug Delivery

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The ophthalmic drug delivery is a challenge in the clinical treatment of ocular diseases. The traditional drug administration usually shows apparent limitations, such as the low bioavailability from the reason of low penetration of the cornea and the short survival time of drug in the eyes. To overcome these shortcomings, we propose an amphiphilic polymer micelle modified with hyaluronic acid (HA) for high efficient ophthalmic delivery of genistein, a widely used hydrophobic drug for treatment of ocular angiogenesis. The MPEG-b-PAE copolymer was synthesized by the Michael addition reaction, and the final drug carrier MPEG-b-PAE-g-HA was obtained by the process of esterification. Then, genistein was packaged in this drug carrier, getting the final micelles with size of about 84.5 nm. The cell viability tests showed that the micelles take no obvious cytotoxicity to the human cornea epithelium cells. The functionalities of drug slow release and cornea penetration ability were demonstrated in a series ex vivo experiments. Further, the vascular inhibition test illustrated that the micelles could significantly inhibit the angiogenesis of human umbilical vein endothelial cells. These results indicate that the constructed polymer has high feasibility to be used as drug carrier in the treatment of ocular diseases.

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“…As shown in Figure 4(b) , by controlling the thickness of the shell upon the GNPs, Zhao et al optimized the detection sensitivity for both CEA and AFP in their sensor [ 93 ]. Chuang et al fabricated a TNF- α sensor by measuring the diffusivity, in which is an immobilized biomarker with and without GNPs on the surface of particles [ 94 ]. Tan et al fabricated a cTn1 sensor based on PEC; a newly developed photocurrent-enhancing nanocomposite was used as a PEC transducer which was made from N-acetyl-L-cysteine capped CdAgTe QDs and dodecahedral GNPs in the sensor.…”

Section: Electrochemical Biomarker Sensorsmentioning

confidence: 99%

Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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Early cancer diagnosis and treatment are crucial research fields of human health. One method that has proven efficient is biomarker detection which can provide real-time and accurate biological information for early diagnosis. This review presents several biomarker sensors based on electrochemistry, surface plasmon resonance (SPR), nanowires, other nanostructures, and, most recently, metamaterials which have also shown their mechanisms and prospects in application in recent years. Compared with previous reviews, electrochemistry-based biomarker sensors have been classified into three strategies according to their optimizing methods in this review. This makes it more convenient for researchers to find a specific fabrication method to improve the performance of their sensors. Besides that, as microfabrication technologies have improved and novel materials are explored, some novel biomarker sensors—such as nanowire-based and metamaterial-based biomarker sensors—have also been investigated and summarized in this review, which can exhibit ultrahigh resolution, sensitivity, and limit of detection (LoD) in a more complex detection environment. The purpose of this review is to understand the present by reviewing the past. Researchers can break through bottlenecks of existing biomarker sensors by reviewing previous works and finally meet the various complex detection needs for the early diagnosis of human cancer.

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Enhanced diffusometric immunosensing with grafted gold nanoparticles for detection of diabetic retinopathy biomarker tumor necrosis factor-α

Cited by 33 publications

References 24 publications

Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles

Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles

Hyaluronic acid modified MPEG-b-PAE block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein

Recent Progress of Biomarker Detection Sensors

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