Enhanced Detection of Diffusion Reductions in Creutzfeldt-Jakob Disease at a Higher B Factor

Susceptibility of Domestic Cats to Chronic Wasting Disease

“…Cerebral atrophy can also become evident on MRI in CJD patients (58). DW-MRI is physiologically based and is a highly sensitive and specific marker of restricted brain diffusion in CJD patients (59,60) and has improved the imaging diagnosis over conventional MRI. Restricted diffusion and DW-MRI signal hyperintensity have been found in the basal ganglia, thalamus, and cortex of CJD patients (60).…”

Multiparameter MR Imaging in the6-OPRIVariant of Inherited Prion Disease

“…35,36 Opposite findings of decreased MD have been reported in sporadic Creutzfeldt-Jakob disease and in patients with the E200K mutation, specifically within the basal ganglia and thalamus, 11,14 thought to reflect spongiform change. A relationship between macroscopic atrophy and microscopic changes reflected in increased MD may be expected; in other neurodegenerative disorders, whole-brain or regional MD values usually increase in association with brain atrophy.…”

“…This approach allowed us to have a more homogeneous cohort and minimize the Clinical Dementia Rating Scale SD across the patient group. Nine individuals with the 6-OPRI mutation were studied (6-OPRI group: mean age, 38.1 Ϯ 3.6 years; median MiniMental State Examination, 19 [range [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]; all codon 129MM). Sixteen healthy volunteers with no history of neurologic disorder were included (Controls group: mean age, 37.1 Ϯ 10.7 years; all Mini-Mental State Examination, 30); Table 1.…”

“…9 Quantitative MR imaging techniques such as MTR and MD mapping have revealed significant regional and whole-brain differences between patients with symptomatic prion disease and control participants. [11][12][13][14] However, these studies used region-ofinterest or histogram analyses, possibly missing or diluting regionally specific changes. VBA of structural images (VBM) 15 or MR imaging measures such as MD or MTR overcome these limitations because they do not require a priori anatomic hypotheses.…”

Imaging of prion diseases

“…In addition, higher b values were recently reported to further increase the sensitivity of DWI for the detection of subtle cases and, this may become an interesting adjunct in borderline situations (12). Restricted diffusion involving the gray matter is the typical finding in CJD although its pathological substrate remains unclear.…”