Enhanced depth imaging optical coherence tomography in patients with different phases of Behcet’s panuveitis

Yeşilırmak, Nilüfer; Lee, Wen-Hsiang; Güngör, Sirel Gür; Pınarcı, Eylem Yaman; Akkoyun, İmren; Yılmaz, Gürsel

doi:10.1016/j.jcjo.2016.07.020

Cited by 15 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, some studies have used EDI-OCT to evaluate choroidal changes in ocular inflammatory disorders [ 5 , 6 ]. Some authors have reported that the patients with active Vogt–Koyanagi–Harada disease [ 5 ] and Behçet disease [ 6 ] exhibit a markedly thickened choroid. Currently, there are a limited number of reports on choroidal thickness change in anterior uveitis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy

Szepessy

Barsi

Kránitz

et al. 2018

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose To describe and correlate the degree of anterior segment inflammation with central retinal and choroidal thickness throughout the treatment period (in the course of follow-up) in the eyes affected with acute anterior uveitis in the patients with seronegative spondyloarthropathy (subgroup: ankylosing spondylitis). Methods Thirty eyes of 30 consecutive Caucasian patients with HLA-B27-associated acute anterior uveitis were included in this study. The flare, AC cell number, and central retinal/choroidal thickness were determined at each visit by optical coherence tomography and laser flare photometry. Treatment consisted of topical corticosteroids. Statistical analysis was performed by MathWorks Matlab software. Results In the follow-up period, central retinal thickness was increased in the first 9-10 days and then decreased until stabilization (after 5-6 weeks). The flare and AC cell number decreased rapidly at the beginning of the treatment, in the first 10 days, and thereafter, slower decrease could be observed until complete resolution of inflammation. Statistically significant, positive correlation was found between initial laser flare value and maximal central retinal thickness (r=0.881, p < 0.001). Positive correlation between flare and retinal thickening was observable throughout the treatment period. Central choroidal thickness was decreased also significantly during the follow-up (p < 0.001). Conclusions The retina and choroid may play a biomarker function in the anterior segment inflammation of the eye in the patients with seronegative spondyloarthropathy.

show abstract

Section: Introductionmentioning

confidence: 99%

The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy

Szepessy

Barsi

Kránitz

et al. 2018

Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…This difference may be due to the systemic disease activity state as in the first study all patients were "inactive" whereas in the latter study the disease activity state was not accessed. An increase in choroidal thickness with systemic inflammatory activity has also been described in Behçet disease [87,88].…”

Section: Spectral Domain Optical Coherence Tomographymentioning

confidence: 82%

The role of ophthalmic imaging in central nervous system degeneration in systemic lupus erythematosus

Dias‐Santos

Proença

Ferreira

et al. 2018

Autoimmunity Reviews

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that can involve any organ system. Central nervous system involvement can be a severe life threatening complication, ultimately resulting in severe neurodegenerative changes. Magnetic resonance imaging suggests that neurodegeneration, which may have deleterious effects on brain function, may occur early in SLE and experimental models suggest that neuroprotection may be feasible and beneficial. The retina is an extension of the brain. Recent ophthalmic imaging technologies are capable of identifying early changes in retinal and choroidal morphology and circulation that may reflect CNS degeneration. However, their utility in monitoring CNS involvement in SLE has been poorly studied as these have only been performed in small cohorts, in a cross-sectional design, non-quantitatively and without correlation to disease activity. The authors aim to review the current understanding of neurodegeneration associated with SLE, with particular focus on the visual pathway. We describe the neuropathology of the visual system in SLE and the evidence for retinal and choroidal neurodegenerative and microvascular changes using optical coherence tomography technology. We aim to describe the potential role of optical imaging modalities in NPSLE diagnosis and their likely impact on the study of neuronal function.

show abstract

“…Fang et al [27] demonstrated that C-reactive protein was significantly negatively related to choroidal thickness before the emergence of ocular symptoms. In patients with uveitis, the choroidal thickness displayed significant changes on OCT [12,13]. Yesilirmak et al [12] found that choroidal thickness was significantly thinner in patients with Behcet's disease-associated uveitis in end-stage phase compared with that in normal subjects.…”

Section: Journal Of Immunology Researchmentioning

confidence: 99%

“…In patients with uveitis, the choroidal thickness displayed significant changes on OCT [12,13]. Yesilirmak et al [12] found that choroidal thickness was significantly thinner in patients with Behcet's disease-associated uveitis in end-stage phase compared with that in normal subjects. Park et al [13] also discovered that choroidal thickness decreased over time in patients with Behcet's disease-associated uveitis and the mean change rate was greater than that in controls (-7.2 versus -2.0 μm/year; P < 0:001).…”

Section: Journal Of Immunology Researchmentioning

confidence: 99%

“…The thickness of the retina and choroid can be affected by both systemic diseases and physiological conditions [7,8]. Several studies have pointed out that the thickness of the retina and choroid in patients with autoimmune disease-associated uveitis displays significant changes on OCT [9][10][11][12][13][14]. However, no research has evaluated the associations between serum RF and thickness of the retina and choroid before the emergence of ocular symptoms.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationships of Rheumatoid Factor with Thickness of Retina and Choroid in Subjects without Ocular Symptoms Using Swept-Source Optical Coherence Tomography

Qian

et al. 2021

Journal of Immunology Research

View full text Add to dashboard Cite

Purpose. Researches have confirmed that the retinal and choroidal thickness in patients with autoimmune disease-associated uveitis displays significant changes. However, the relationships between rheumatoid factor (RF) and thickness of the retina and choroid in individuals without ocular manifestations remain unclear. The aim of this study is to assess the associations of RF with retinal and choroidal thickness. Methods. The individuals enrolled in the cross-sectional research received full ocular examinations. The participants were classified as the RF (+) group ( RF ≥ 15.0 IU/ml) and the RF (−) group ( RF < 15.0 IU/ml) according to the serum RF titers. The thickness of the retina and choroid was measured by swept-source optical coherence tomography (SS-OCT). Results. The study covered 65 right eyes of 65 individuals that are RF-positive and 130 right eyes of 130 age- and sex-matched individuals that are RF-negative. The RF (+) group showed decreased choroidal thickness that achieved statistical significance only in the outer inferior and outer temporal sectors, as compared to the RF (−) group. There was no statistically significant difference regarding the retinal thickness between the two groups. Pearson’s correlation analysis revealed that the RF was significantly negatively related to the choroidal thickness in all areas. However, there was no significant correlation between the RF and the retinal thickness. Conclusions. Serum RF titers are closely linked with choroidal thickness before the emergence of ocular symptoms. Research into the relationships may improve our understanding of the role of serum RF in the pathogenesis of uveitis.

show abstract

Enhanced depth imaging optical coherence tomography in patients with different phases of Behcet’s panuveitis

Cited by 15 publications

References 33 publications

The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy

The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy

The role of ophthalmic imaging in central nervous system degeneration in systemic lupus erythematosus

Relationships of Rheumatoid Factor with Thickness of Retina and Choroid in Subjects without Ocular Symptoms Using Swept-Source Optical Coherence Tomography

Contact Info

Product

Resources

About