Enhanced delivery of drugs into and across the skin by ethosomal carriers

Touítou, Elka; Godin, Biana; Weiss, Celeste

doi:10.1002/1098-2299(200007/08)50:3/4<406::aid-ddr23>3.0.co;2-m

Cited by 159 publications

(79 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The release of the therapeutic agent occurs by the fusion of these vesicles into cell membranes in the deeper layers of the skin. 6,[124][125][126][127][128] It is suggested that transethosomes have superior skin-permeation properties over classical ethosomes. This is because transethosomes contain both ethanol and the edge activator or the penetration enhancer, which both act together to increase vesicular malleability and skin-lipid perturbation.…”

Section: Mechanisms Of Ethosomal System Skin Permeationmentioning

confidence: 99%

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

285

205

View full text Add to dashboard Cite

Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential), entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems.

show abstract

Section: Mechanisms Of Ethosomal System Skin Permeationmentioning

confidence: 99%

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

285

205

View full text Add to dashboard Cite

show abstract

“…When ethosomal carriers, which contain ethanol, and soft small vesicles are applied to the skin a number of concomitant processes may take place, involving the stratum corneum and pilosebaceous pathway. Evidence of existence of the follicular transport pathway taken by the lipid vesicles have been reported [7][8][9][10][11][12][13][14][15][16][17]. first, ethanol disturbs the organization of the stratum corneum lipid bilayer and enhances its lipid fluidity.…”

Section: Figure 7 In Vitro Release Of Aceclofenac From Mouse Skinmentioning

confidence: 99%

Ethosome for enhanced transdermal drug delivery of aceclofenac.

Dave¹,

Kumar²,

Lewis³

et al. 2010

Int. J. Drug Delivery

View full text Add to dashboard Cite

The aim of the current investigation is to evaluate the transdermal potential of novel vesicular carrier, ethosomes, bearing aceclofenac, Non-steroidal antiinflammatory drugs (NSAIDs) agents having limited transdermal permeation. Aceclofenac loaded ethosomal carriers were prepared, optimized and characterized for vesicular shape and surface morphology,(SEM) scanning electronic microscopy, vesicular size, entrapment efficiency, stability, invitro release study. The formulation (Etho5) having 3% phospholipids contant and 40% ethanol showing the grater entrapment (93.3%) and optimal average vesicle size of formulation (Etho5) determine by Malvern Zetamaster ZEM & 0.696µm and zeta potential of formulation was -6.74 mV. The formulation (Etho12) having 3% phospholipids contant and 40% isopropyl alcohol showing the grater entrapment (95.7%). stability profile of prepared system assessed for 45 days. The vesicular suspension was kept in sealed vials (10ml) at 4 ± 2ºC and at room temperature for 45 days no change is shown in the entrapment efficiency. The optimized ethosomal formulation showed transdermal flux (226.1 µg/cm²/hr) for ethanolic drug solution which is grater then that of isopropyl alcohol solution (159.0 µg/cm²/hr). The result advocates the potential of ethosome formulation to treat rheumatic disease where facilitated penetration of the drug into muscle and synovial fluid is desirable. In light of the data obtained from experimental work we can expect the ethosome formulation to be safe and very efficient as a drug carrier for systemic as well as topical delivery of drug, holding future in effective transdermal delivery.

show abstract

“…The ethosomes would not be well suited to entrap hydrophilic solutes. 33 A key difference with TRS is that ethosomes can be successfully applied under occlusive conditions, which allows for the employing of patches. In spite of the high ethanol concentration, the average size and size distribution of ethosomes remains constant for at least 2 years at room temperature.…”

mentioning

confidence: 99%

“…63 Moreover, the entrapment of hydrophilic molecules in ethosomes is less efficient than that of hydrophobic molecules. 33 This work showed that, in vivo, the fluorescence intensity of PpIX was maximal after topical application of ALA in phosphatidylethanolamine (PE) ethosomes (minimal EE with 90% external ALA versus maximal EE for PE:cholesterol (Chol):sodium stearate (SS) ethosomes) as compared to that achieved by ALA in aqueous solution, ethanolic solution, and liposomes. In accordance with previously reported experimental evidence, 64 a correlation between EE and PpIX delivery to an epidermal target was absent.…”

mentioning

confidence: 99%

Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

Romero¹,

Morilla²

2013

IJN

View full text Add to dashboard Cite

Vesicles that are specifically designed to overcome the stratum corneum barrier in intact skin provide an efficient transdermal (systemic or local) drug delivery system. They can be classified into two main groups according to the mechanisms underlying their skin interaction. The first group comprises those possessing highly deformable bilayers, achieved by incorporating edge activators to the bilayers or by mixing with certain hydrophilic solutes. The vesicles of this group act as drug carriers that penetrate across hydrophilic pathways of the intact skin. The second group comprises those possessing highly fluid bilayers, owing to the presence of permeation enhancers. The vesicles of this group can act as carriers of drugs that permeate the skin after the barrier of the stratum corneum is altered because of synergistic action with the permeation enhancers contained in the vesicle structure. We have included a detailed overview of the different mechanisms of skin interaction and discussed the most promising preclinical applications of the last five years of Transfersomes ® (IDEA AG, Munich, Germany), ethosomes, and invasomes as carriers of antitumoral and anti-inflammatory drugs applied by the topical route.

show abstract

Enhanced delivery of drugs into and across the skin by ethosomal carriers

Cited by 159 publications

References 34 publications

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Ethosome for enhanced transdermal drug delivery of aceclofenac.

Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

Contact Info

Product

Resources

About