Enhanced De Novo Neurogenesis and Dopaminergic Neurogenesis in the Substantia Nigra of 1‐Methyl‐4‐phyenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinson's Disease‐Like Mice

Abstract

ABSTRACT

Serotonin Depletion Hampers Survival and Proliferation in Neurospheres Derived from Adult Neural Stem Cells

“…Migration is an important functional feature that is preferentially displayed by lineage-committed precursors and migratory properties could theoretically be exploited for cell-based therapeutics of CNS diseases (Corti et al, 2005;Ikegami et al, 2005;Prestoz et al, 2001;Seki, 2002;Shan et al, 2006). We show here for the first time that neural cells dissociated from serially passaged adult hippocampal neurospheres display increased migration activity in response to 5-HT in vitro.…”

Therapeutic Potentials of Human Embryonic Stem Cells in Parkinson’s Disease

“…Although the initial TUNEL assay showed a decrease in TH neurons within the SN at 12 weeks, the total TH neuronal number remained constant over the life of the animals. In support of this finding, Shan et al 67 reported an increase, although a small one, in DA neurogenesis in the SN at basal levels; these cells were derived from neural progenitor. After lesioning, nestin-Lac-Z transgenic mice showed an increase in DA neurogenesis with cells derived from neural progenitor and BrdU labeled cells, thus suggesting that multiple cells are responsible for the DA neurogenesis.…”

Dopamine D3Receptor Agonist Delivery to a Model of Parkinson's Disease Restores the Nigrostriatal Pathway and Improves Locomotor Behavior

“…The neurogenic capacity of D 3 receptor activation may not be restricted to the SVZ, however. Indeed, low levels of dopamine D 3 receptor expression have also been described in the SN (Diaz et al, 2000), a region of the adult brain shown to exhibit ongoing cytogenesis and neurogenic potential (Lie et al, 2002;Zhao et al, 2003;Shan et al, 2006). Furthermore, we have previously demonstrated a significant induction of neurogenesis in the SN C of the adult rat brain in response to D 3 agonist treatment (Van Kampen and Robertson, 2005).…”

“…More recently, restricted progenitor cells have been identified in various "quiescent" regions of the adult brain including the striatum (Palmer et al, 1995;Pencea et al, 2001) and the SN (Lie et al, 2002;Zhao et al, 2003;Shan et al, 2006). Additional understanding of the microenvironmental signals regulating the proliferation of these cells would allow us the opportunity to enhance neuronal production and provide us with valuable tools for the development of new treatment strategies.…”