Enhanced cytotoxicity of anticancer drug delivered by novel nanoscale polymeric carrier

Stoika, Rostyslav; Boiko, N. M.; Senkiv, Julia; Shlyakhtina, Yelyzaveta; Panchuk, R. R.; Finiuk, Nataliya; Filyak, Yevhen; Bilyy, Rostyslav; Kit, Yu. Ya.; Skorohyd, N. R.; Klyuchivska, Olga; Zaichenko, Alexander; Mitina, Nataliya; Ryabceva, A

doi:10.1088/1742-6596/429/1/012038

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2016

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“…Water‐soluble C 60 ‐PEG conjugate is accumulated and kept for more long time in the tumor than in normal tissues . The polymeric carrier doxorubicin‐PEG facilitated a better penetration of cytostatic and enhanced biological action in murine leukemia cell L1210 .…”

Section: Resultsmentioning

confidence: 99%

Combined action of C₆₀ fullerene with dimethyl‐N‐(benzoyl)amidophosphate or dimethyl‐N‐(phenylsulfonyl)amidophosphate on leukemia L1210 cells in silico and in vitro

Grynyuk

Prylutska

Franskevych

et al. 2016

Materialwissenschaft Werkst

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The interaction of dimethyl-N-(benzoyl)amidophosphate (HCP) and dimethyl-N-(phenylsulfonyl)amidophosphate (HSP) compounds and C 60 fullerene with DNA was studied by use of molecular modeling. It was demonstrated that DNA-HCP complex is more stable as compared to the DNA-HSP one. The ability of C 60 fullerene to form a stable complex with minor groove of DNA was shown. Under combined action of 10 -5 M C 60 fullerene and 2.5 × 10 -4 M HCP the viability of leukemia L1210 cells was decreased by 37% in 24 h. The observed cytotoxic effect was intensified in 48 h. HSP compound alone as well as at combined action with C 60 fullerene showed no cytotoxic effect.

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Section: Resultsmentioning

confidence: 99%

Combined action of C₆₀ fullerene with dimethyl‐N‐(benzoyl)amidophosphate or dimethyl‐N‐(phenylsulfonyl)amidophosphate on leukemia L1210 cells in silico and in vitro

Grynyuk

Prylutska

Franskevych

et al. 2016

Materialwissenschaft Werkst

View full text Add to dashboard Cite

show abstract

Enhanced cytotoxicity of anticancer drug delivered by novel nanoscale polymeric carrier

Cited by 1 publication

References 7 publications

Combined action of C₆₀ fullerene with dimethyl‐N‐(benzoyl)amidophosphate or dimethyl‐N‐(phenylsulfonyl)amidophosphate on leukemia L1210 cells in silico and in vitro

Combined action of C₆₀ fullerene with dimethyl‐N‐(benzoyl)amidophosphate or dimethyl‐N‐(phenylsulfonyl)amidophosphate on leukemia L1210 cells in silico and in vitro

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Enhanced cytotoxicity of anticancer drug delivered by novel nanoscale polymeric carrier

Cited by 1 publication

References 7 publications

Combined action of C60 fullerene with dimethyl‐N‐(benzoyl)amidophosphate or dimethyl‐N‐(phenylsulfonyl)amidophosphate on leukemia L1210 cells in silico and in vitro

Combined action of C60 fullerene with dimethyl‐N‐(benzoyl)amidophosphate or dimethyl‐N‐(phenylsulfonyl)amidophosphate on leukemia L1210 cells in silico and in vitro

Contact Info

Product

Resources

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Combined action of C₆₀ fullerene with dimethyl‐N‐(benzoyl)amidophosphate or dimethyl‐N‐(phenylsulfonyl)amidophosphate on leukemia L1210 cells in silico and in vitro

Combined action of C₆₀ fullerene with dimethyl‐N‐(benzoyl)amidophosphate or dimethyl‐N‐(phenylsulfonyl)amidophosphate on leukemia L1210 cells in silico and in vitro