Enhanced creative thinking under dopaminergic therapy in Parkinson disease

Faust-Socher, Achinoam; Kenett, Yoed N.; Cohen, Oren S.; Hassin‐Baer, Sharon; Inzelberg, Rivka

doi:10.1002/ana.24181

Cited by 61 publications

(42 citation statements)

References 35 publications

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“…This includes sudden interest in poetry (Schrag and Trimble 2001;Joutsa et al 2012), writing and embroidery (Bindler et al 2011), and painting (Chatterjee et al 2006), as well as dramatic changes in artistic style in already established artists (Kulisevsky et al 2009;Lopez-Pousa et al 2012;Shimura et al 2012). These patients also perform better than controls on tasks frequently used to estimate creative potential (Faust-Socher et al 2014). Moreover, this creative boost is lost following withdrawal of DA treatment, thus suggesting a strong link between creativity and DA medication in these patients (Bindler et al 2011;Lhommee et al 2014).…”

Section: Hemispheric Reward Asymmetry and Hemispheric Asymmetries In mentioning

confidence: 96%

The “Creative Right Brain” Revisited: Individual Creativity and Associative Priming in the Right Hemisphere Relate to Hemispheric Asymmetries in Reward Brain Function

2016

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The idea that creativity resides in the right cerebral hemisphere is persistent in popular science, but has been widely frowned upon by the scientific community due to little empirical support. Yet, creativity is believed to rely on the ability to combine remote concepts into novel and useful ideas, an ability which would depend on associative processing in the right hemisphere. Moreover, associative processing is modulated by dopamine, and asymmetries in dopamine functionality between hemispheres may imbalance the expression of their implemented cognitive functions. Here, by uniting these largely disconnected concepts, we hypothesize that relatively less dopamine function in the right hemisphere boosts creativity by releasing constraining effects of dopamine on remote associations. Indeed, participants with reduced neural responses in the dopaminergic system of the right hemisphere (estimated by functional MRI in a reward task with positive and negative feedback), displayed higher creativity (estimated by convergent and divergent tasks), and increased associative processing in the right hemisphere (estimated by a lateralized lexical decision task). Our findings offer unprecedented empirical support for a crucial and specific contribution of the right hemisphere to creativity. More importantly our study provides a comprehensive view on potential determinants of human creativity, namely dopamine-related activity and associative processing.

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Section: Hemispheric Reward Asymmetry and Hemispheric Asymmetries In mentioning

confidence: 96%

The “Creative Right Brain” Revisited: Individual Creativity and Associative Priming in the Right Hemisphere Relate to Hemispheric Asymmetries in Reward Brain Function

2016

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“…Similar meaningful, creative, and collaborative endeavours [88] have been shown to improve a sense of life control and selfesteem [89]. Recent research has also indicated that people with PD taking dopaminergic drugs may demonstrate enhanced visual and verbal creativity [90], so choral singing may offer an outlet for this.…”

Section: Qol In Group Singingmentioning

confidence: 99%

Choral singing therapy following stroke or Parkinson’s disease: an exploration of participants’ experiences

Fogg‐Rogers

Buetow

Talmage

et al. 2015

Disability and Rehabilitation

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“…To examine this issue, motor performance of patients with chronic stroke was measured as each played two different versions of a popular video game, one PC-based and one AR-based. The two versions required the same arm movement kinematics to control the game but differed in level of cognitive demand, which was higher with the PC approach because it uncouples a subject’s eye and hand movements and requires the subject to perform a visuospatial transform 16, 17 . Increased cognitive demand is an important consideration when designing computerized therapies to promote stroke rehabilitation 18–20 .…”

Section: Introductionmentioning

confidence: 99%

Choice of Human–Computer Interaction Mode in Stroke Rehabilitation

Hondori

Khademi

Dodakian

et al. 2015

Neurorehabil Neural Repair

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Background and objective Advances in technology are providing new forms of human-computer interaction. The current study examined one form of human-computer interaction, augmented reality (AR), whereby subjects train in the real world workspace with virtual objects projected by the computer. Motor performances were compared with those obtained while subjects used a traditional human-computer interaction, i.e., a personal computer (PC) with a mouse. Methods Patients used goal-directed arm movements to play AR and PC versions of the Fruit Ninja video game. The two versions required the same arm movements to control the game but had different cognitive demands. With AR, the game was projected onto the desktop, where subjects viewed the game plus their arm movements simultaneously, in the same visual coordinate space. In the PC version, subjects used the same arm movements but viewed the game by looking up at a computer monitor. Results Among 18 patients with chronic hemiparesis after stroke, the AR game was associated with 21% higher game scores (p=0.0001), 19% faster reaching times (p=0.0001), and 15% less movement variability (p=0.0068), as compared to the PC game. Correlations between game score and arm motor status were stronger with the AR version. Conclusions Motor performances during the AR game were superior to those during the PC game. This result is due in part to the greater cognitive demands imposed by the PC game, a feature problematic for some patients but preferred for others. Mode of human-computer interface influences rehabilitation therapy demands and can be individualized for patients.

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Enhanced creative thinking under dopaminergic therapy in Parkinson disease

Cited by 61 publications

References 35 publications

The “Creative Right Brain” Revisited: Individual Creativity and Associative Priming in the Right Hemisphere Relate to Hemispheric Asymmetries in Reward Brain Function

The “Creative Right Brain” Revisited: Individual Creativity and Associative Priming in the Right Hemisphere Relate to Hemispheric Asymmetries in Reward Brain Function

Choral singing therapy following stroke or Parkinson’s disease: an exploration of participants’ experiences

Choice of Human–Computer Interaction Mode in Stroke Rehabilitation

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