Enhanced Content of IgG in Burkitt’s Lymphoma Cells after Treatment with the Topoisomerase II Inhibitor, Lucanthone

Conversion of IgM to IgG by Lysates of Burkitt’s Lymphoma Cells

“…Mass spectroscopy analysis of the 20 kDa to 5 kDa fractions showed that they contained immunoproteins, as well as some proteins with catalytic activity, perhaps responsible for release of IgG from IgM. These experiments may provide clues to cell mechanisms responsible for the increased content of IgG found in Burkitt's lymphoma cells after lucanthone and ionizing radiation treatment [2,3]. Incubation of exogenous or endogenous IgM with partially purified cell lysates released IgG immunopositive species.…”