Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization
Angela Imere,
Nicola C. Foster,
Hadi Hajiali
et al.
Abstract:Cartilage tissue engineering aims to develop functional substitutes for treating cartilage defects and osteoarthritis. Traditional two-dimensional (2D) cell culture systems lack the complexity of native cartilage, leading to the development of 3D regenerative cartilage models. In this study, we developed a 3D model using Gelatin Methacryloyl (GelMA)-based hydrogels seeded with Y201 cells, a bone marrow mesenchymal stem cell line. The model investigated chondrogenic differentiation potential in response to Wnt3… Show more
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