Enhanced Chemotactic and Phagocytic Activities of Leukocytes in Psoriasis Vulgaris

Wahba, Asher; Cohen, Haim A.; Bar‐Eli, Menashe; Gallily, Ruth

doi:10.1111/1523-1747.ep12547117

Cited by 119 publications

(34 citation statements)

References 10 publications

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“…The migration of psoriatic PMN in response to various chemoattractants has been reported as being increased [1][2][3][4], decreased or unaltered [5 7], Different methodologies have been employed, which include the capillary. Boyden chamber, and the under-agarose methods [8].…”

Section: Introductionmentioning

confidence: 99%

Polymorphonuclear Leucocyte Chemotaxis in Response to Leukotriene B<sub>4</sub> in Treated and Untreated Psoriatics

Green

Ferguson²,

Macleod³

et al. 1989

Dermatology

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Various chemoattractants have been implicated in the aetiology of the polymorphonuclear leucocyte (PMN) migration into the epidermis seen in early lesions of psoriasis. Using an underagarose technique, the in vitro chemotactic responses of PMN to the arachidonic acid lipoxygenase product leukotriene B₄ (LTB₄) were assayed in five groups of subjects: normal healthy volunteers (n = 12), untreated psoriatics (n = 11) and psoriatics treated with topical tar (n = 12), PUVA (n = 11) and UVB phototherapy (n = 10). No significant difference was observed between the responses of control subjects and of untreated psoriatics, nor between the untreated psoriatic group and the PUVA- and UVB-treated groups, respectively. However, comparison of the tar-treated and untreated groups revealed a significantly increased chemotactic response to LTB₄ in the tar-treated group (p < 0.01).

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Section: Introductionmentioning

confidence: 99%

Polymorphonuclear Leucocyte Chemotaxis in Response to Leukotriene B<sub>4</sub> in Treated and Untreated Psoriatics

Green

Ferguson²,

Macleod³

et al. 1989

Dermatology

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“…clear-cut in pustular psoriasis, where the neutrophil granulocytes play a major role, but is also present, though at a lesser degree, in patients affected with plaque-type psoriasis [7,8]. The same phe nomenon is also determined by another ret inoid, the 13cis retinoic acid Isotretinoin.…”

Section: Discussionmentioning

confidence: 99%

Effects of Isotretinoin on the Neutrophil Chemotaxis in Cystic Acne

et al. 1983

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“…Chemotactic responsiveness in psoriatics was found normal [24, 56, 57], increased [58][59][60][61][62][63] and decreased [64]. Activ ities of neutral serine proteases in psoriasis have been reported to be increased [65] and normai [66], A remarkable association of PMN functions with the clinical manifesta tion of psoriasis has been shown by Glinski et al [67].…”

Section: Circulating Blood Pmnmentioning

confidence: 99%

Migration of Polymorphonuclear Leukocytes in Psoriasis

Kerkhof

Chang²

1989

Skin Pharmacol Physiol

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A characteristic feature of the early and active psoriatic lesion is the intraepidermal penetration of polymorphonuclear leukocytes (PMN) with the formation of intraepidermal micropustules of Kogoj and microabscesses of Munro, localized in the stratum corneum. In pustular psoriasis the accumulation of PMN dominates the clinical picture. During the last decade our insight into the regulation of the migration of PMN has increased. The properties of the circulating blood PMN and the biochemical nature and biological effects of mediators of inflammation have been studied in detail. Several groups have demonstrated that the transdermal and epidermal migration of PMN following challenge with a chemoattractant is slightly diminished in the clinically uninvolved skin and profoundly decreased in the lesional skin of psoriatics, compared to the responsiveness in normal controls. The molecular nature of this process of tachyphylaxis has not yet been established. However, it has been hypothesised that some mediators of inflammation, cytochrome P-450, endothelial cell function, and protease inhibitors might be of relevance in this respect. This report is a review of the literature on transdermal and epidermal migration of PMN in normal and psoriatic skin. The aim of this review is to clarify further the position of the PMN in the pathogenesis of psoriasis and its role as a target for antipsoriatic treatments.

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Enhanced Chemotactic and Phagocytic Activities of Leukocytes in Psoriasis Vulgaris

Cited by 119 publications

References 10 publications

Polymorphonuclear Leucocyte Chemotaxis in Response to Leukotriene B<sub>4</sub> in Treated and Untreated Psoriatics

Polymorphonuclear Leucocyte Chemotaxis in Response to Leukotriene B<sub>4</sub> in Treated and Untreated Psoriatics

Effects of Isotretinoin on the Neutrophil Chemotaxis in Cystic Acne

Migration of Polymorphonuclear Leukocytes in Psoriasis

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