Enhanced Chemoradiotherapy for MRSA‐Infected Osteomyelitis Using Immunomodulatory Polymer‐Reinforced Nanotherapeutics
Yufei Zhang,
Yijie Cheng,
Zhe Zhao
et al.
Abstract:The eradication of osteomyelitis caused by methicillin‐resistant Staphylococcus aureus (MRSA) poses a significant challenge due to its development of biofilm‐induced antibiotic resistance and impaired innate immunity, which often leads to frequent surgical failure. Here, we report the design, synthesis, and performance of X‐ray‐activated polymer‐reinforced nanotherapeutics that modulate the immunological properties of infectious microenvironments to enhance chemoradiotherapy against multidrug‐resistant bacteri… Show more
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