Enhanced chemodynamic therapy and immunotherapy by hypoxia augmentation for tumor ablation

Defect-rich sonosensitizers based on CeO2 with Schottky heterojunctions for boosting sonodynamic/chemodynamic synergistic therapy

“…The hydroxyl radicals generated were also proved by ESR spectroscopy with 5,5-dimethyl-1-pyrroline N -oxide (DMPO). 54 In contrast to Pt/CeO 2− x S x and H 2 O 2 groups, the characteristic ˙OH (1 : 2 : 2 : 1) signal can only be observed in the Pt/CeO 2− x S x + H 2 O 2 group, further demonstrating the ˙OH generation through the POD-like reaction catalyzed by Pt/CeO 2− x S x (Fig. 3f).…”

Nanodelivery Systems as a Novel Strategy to Overcome Treatment Failure of Cancer

“…Consequently, these improvements enhanced the antitumor immune response and increased the efficacy of tumor therapy by promoting M1 polarization. [ 131 ] Wan et al. designed a nanoparticle NP‐PDT@Reg to deliver a vascular normalizing agent (Figure 3C).…”

Self-evolving persistent luminescence nanoprobes for autofluorescence-free ratiometric imaging and on-demand enhanced chemodynamic therapy of pulmonary metastatic tumors

“…), CDT relies on the Fenton or Fenton-like reaction to decompose H 2 O 2 into toxic ˙OH, which disrupts the redox balance of the cells and inhibits tumor cell growth and metastasis. 25–28 The mild acidity and overexpression of H 2 O 2 in the TME can be employed as endogenous activation reagents of CDT, offering the possibility of on-demand therapy. 29,30 However, the TME also contains a high concentration of reduced glutathione (GSH), which neutralizes the generated ˙OH and maintains cellular redox homeostasis, thus affecting CDT efficiency.…”