Enhanced chemiluminescence of the luminol-hydrogen peroxide system by colloidal cupric oxide nanoparticles as peroxidase mimic

Chen, Wei; Hong, Liping; Liu, Ailin; Liu, Jianqing; Lin, Xinhua; Xia, Xing‐Hua

doi:10.1016/j.talanta.2012.06.061

Cited by 128 publications

(69 citation statements)

References 57 publications

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“…A homogeneous CL immunoassay for thyroxine (T4) present in serum samples was also described [90]. A very sensitive LCL enhancement-based detection method was developed for hydrogen peroxide and glucose using cupric oxide nanoparticles as enhancers for LCL [91]. …”

Section: Biosensorsmentioning

confidence: 99%

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Khan

Idrees

Moxley

et al. 2014

Appl Biochem Biotechnol

234

181

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Chemiluminescence (CL) is an important method for quantification and analysis of various macromolecules. A wide range of CL agents such as luminol, hydrogen peroxide, fluorescein, dioxetanes and derivatives of oxalate, and acridinium dyes are used according to their biological specificity and utility. This review describes the application of luminol chemiluminescence (LCL) in forensic, biomedical, and clinical sciences. LCL is a very useful detection method due to its selectivity, simplicity, low cost, and high sensitivity. LCL has a dynamic range of applications, including quantification and detection of macro and micromolecules such as proteins, carbohydrates, DNA, and RNA. Luminol-based methods are used in environmental monitoring as biosensors, in the pharmaceutical industry for cellular localization and as biological tracers, and in reporter gene-based assays and several other immunoassays. Here, we also provide information about different compounds that may enhance or inhibit the LCL along with the effect of pH and concentration on LCL. This review covers most of the significant information related to the applications of luminol in different fields.

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Section: Biosensorsmentioning

confidence: 99%

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Khan

Idrees

Moxley

et al. 2014

Appl Biochem Biotechnol

234

181

View full text Add to dashboard Cite

show abstract

“…The present method was compared to other reported analytical methods [35,[55][56][57][58][59][60][61][62] that use a CL system for H 2 O 2 and glucose analysis in terms of linear ranges and LoDs. As seen in Table 2, the proposed CL method provides high sensitivity without the need for labeling, immobilization, or expensive instrumentation, and affords good reproducibility in H 2 O 2 and glucose analysis.…”

Section: Calibration Curves For H 2 O 2 and Glucose Detectionmentioning

confidence: 99%

Imidazolium-based ionic liquid derivative/CuII complexes as efficient catalysts of the lucigenin chemiluminescence system and its application to H2O2 and glucose detection

et al. 2015

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The effects of six synthetic imidazolium-based ionic liquids (ILs) on the Cu(II)-catalyzed chemiluminescence of lucigenin (Luc-CL) in the pH range 6.0-11 were investigated. Preliminary experiments found that the CL emission was strongly enhanced or inhibited in the presence of the ILs. The degree of enhancement or inhibition of the CL intensity in the presence of each IL was related to the molecular structure of the IL, the medium used, and the pH. The maximum enhancement of the CL intensity was observed at pH 9.0 (amplification factor = 443). This decrease in the pH at which maximum CL enhancement occurred and the substantial signal amplification of the Luc-CL may be related to a strong interaction between Cu(II) and the imidazolium ring of superior ILs at this pH. Additionally, the formation of IL microdomains in semi-aqueous media permitted more solubility of the product yielded by the Luc-CL reaction (N-methylacridone), which could increase the CL intensity. To obtain consistent data on the catalytic efficiency of Cu(II) in the presence of various ILs as well as the corresponding CL emission intensities, fluorescence quantum yields (Φ F) of lucigenin were measured under the same conditions. Comparison of the data pointed to the mechanism that controls the properties of Luc-CL in the presence of the Cu(II)/IL complexes. Based on the catalytic effect of the Cu(II)/IL complex and the measurement of the enzymatically generated H2O2, a novel, simple, and sensitive CL method for determining glucose with a detection limit (LoD) of 6.5 μM was developed. Moreover, this method was satisfactorily applied to the determination of glucose in human serum and urine samples. Graphical Abstract The lucigenin chemiluminescence assay for H2O2 and glucose using imidazolium-based ionic liquid derivatives/Cu(II) complexes as efficient catalysts at pH 9.0.

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“…Luminol-H 2 O 2 CL reaction, as a popular CL reaction, has been widely applied for the determination of various substances [6][7][8]. Several kinds of catalysts including enzymes [9], metal ions [10], and nanoparticles [11][12][13][14][15][16] were reported as effective catalyst of luminol-H 2 O 2 CL reaction. Among them, horseradish peroxidase (HRP) is the most commonly used catalyst in luminol-H 2 O 2 CL reaction, and has been widely used for the detection of hydrogen peroxide and other compounds through coupled enzymatic reactions.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, several kinds of nanoparticles including Au NPs [12], CuO NPs [13], Co 3 O 4 NPs [14], Au nanocluster [15], Pt NPs [16], etc. were reported to give peroxidase-mimic properties and to catalyze the luminol-H 2 O 2 reaction to emit light.…”

Section: Introductionmentioning

confidence: 99%

Iodophenol blue-enhanced luminol chemiluminescence and its application to hydrogen peroxide and glucose detection

Wang

Zhao

et al. 2016

Talanta

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Enhanced chemiluminescence of the luminol-hydrogen peroxide system by colloidal cupric oxide nanoparticles as peroxidase mimic

Cited by 128 publications

References 57 publications

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Imidazolium-based ionic liquid derivative/CuII complexes as efficient catalysts of the lucigenin chemiluminescence system and its application to H2O2 and glucose detection

Iodophenol blue-enhanced luminol chemiluminescence and its application to hydrogen peroxide and glucose detection

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