Enhanced chemiluminescence determination of paracetamol

Abstract

Due to the severe consequences of potential overdoses of paracetamol (PCM) on the human body, the measurement of PCM in pharmaceutical and biological samples is essential.

Sensitive and selective determination of paracetamol in antipyretic children's syrup with a polyglycine modified glassy carbon electrode

“…According to articles that have been published until now there are different advanced, refined and sensitive methods that have been applied for the determination of ACOP i.e. , titrimetric, 13–15 colorimetry, 16–19 spectrophotometry and spectroscopy, 20–23 gas chromatography, 24–28 near-infrared transmittance spectroscopy, 29–32 high performance liquid chromatography (HPLC), 33–35 chemiluminescence, 36–39 fluorescence, 40–43 liquid chromatography tandem mass spectrometry, 44–46 capillary electrophoresis 47,48 and thin-layer chromatography (TLC). 49,50…”

Cationic AIEgen micelle-improved chemiluminescent H2O2 assay by integrating reactant approach and CRET

“…In addition, the introduction of fluorophores with spectral overlap with the emission of luminol radicals has also been explored to boost the CL intensity in the micelle system via CRET. 22 CRET not only enhances CL intensity, but also allows for ratiometric sensing applications with high accuracy. 23 Despite the enhanced CL intensity upon the introduction of extra fluorophores, the CRET efficiency is largely affected by the distance between luminol radicals and fluorophores as well as the self-quenching effect of conventional fluorophores.…”

From glow-sticks to sensors: single-electrode electrochemical detection for paper-based devices

“…12,13 Towards these goals, a wide variety of detection methodologies have been implemented in multiplex systems, including colorimetry, fluorescence, 14,15 surface plasmon resonance, 16,17 electrochemistry, 17,18 and chemiluminescence. 19,20 Although each of these strategies offer specific advantages, these detection systems often require specific instrumentation and operating parameters, which limit their application.…”

“…12,13 Towards these goals, a wide variety of detection methodologies have been implemented in multiplex systems, including colorimetry, fluorescence, 14,15 surface plasmon resonance, 16,17 electrochemistry, 17,18 and chemiluminescence. 19,20 Although each of these strategies offer specific advantages, these detection systems often require specific instrumentation and operating parameters, which limit their application. Alternatively, electrochemiluminescence (ECL, also known as electrogenerated chemiluminescence) has emerged as one of the simplest, most sensitive, and versatile detection platforms that has been applied for a wide range of analytes.…”