Enhanced Characterization of Pyrene Binding in Mixed Cyclodextrin Systems via Fluorescence Spectroscopy

Levine, Mindy; Smith, Benjamin

doi:10.1007/s10895-020-02572-5

Cited by 10 publications

(4 citation statements)

References 37 publications

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“…The polarity index for hydrophilic Alg is close to that of water (1.67), [38][39][40] but that of AlgCD is lower (1.54) as the pyrene is complexed by CD cavity. [43][44][45] For diluted NaPA solution, the value of polarity ratio is similar with that of water. This behavior is the result that the probe encounters hydrophilic medium as the electrostatic repulsive forces between COO − groups impede the polymer coil shrink and to form a hydrophobic microdomains to accommodate the pyrene.…”

Section: Steady State Fluorescence Spectroscopymentioning

confidence: 81%

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Physicochemical Changes of Alginate and Polyacrylate Mixture Induced by Interactions of the Appended Units

Leontieş

Băran

Ioniţă

et al. 2023

Macro Chemistry & Physics

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This study aims to analyze the physicochemical properties of solutions containing the mixture of polyacrylates functionalized with alkyl chains moieties and alginate (Alg) functionalized with 𝜷-cyclodextrins (CD). Functionalization of anionic polymers with host (CD) and guest units (alkyl chain) allow local host-guest interaction which determines discrete changes in properties of the resulted mixtures. The systems are investigated by surface tension, viscosity, and zeta-potential measurements, Fourier transform infrared (FTIR), UV-vis, fluorescence, and electron paramagnetic resonance spectroscopies. Spectroscopic methods reveal the local changes induced by the formation of host-guest interactions in modified polyacrylates and modified Alg which explain the macroscopic parameters of solutions such as viscosity, surface tension, and zeta potential. The host-guest interactions stabilize the repulsive forces between the anionic polymers and influence the formation of intercoil of functionalized polyacrylates. The practical application comprises in crystal violet incorporation in the polymeric mixtures and reveals that dyes' properties, such as solubilization and stabilization, may be enhanced. Valuable information, related to the conformational changes generated by the particular formulations of these polymer mixtures, is obtained. The results have the potential applications in chemical sensing, molecular recognition, and the printing industry.

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Section: Steady State Fluorescence Spectroscopymentioning

confidence: 81%

“…The polarity index for hydrophilic Alg is close to that of water (1.67), [ 38–40 ] but that of AlgCD is lower (1.54) as the pyrene is complexed by CD cavity. [ 43–45 ]…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Changes of Alginate and Polyacrylate Mixture Induced by Interactions of the Appended Units

Leontieş

Băran

Ioniţă

et al. 2023

Macro Chemistry & Physics

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“…S7, ESI †), suggesting that the supramolecular encapsulation of Zn-1 by FBcCyD suppresses the non-radiative decay of the excited state. 26 Although the cCyD cavity forms a pyrene dimer that exhibits dimeric fluorescence at approximately 500 nm, 27 this was not observed for the supramolecular complex of FBcCyD with Zn-1. This finding suggests that FBcCyD and Zn-1 form a supramolecular complex in a 1 : 1 stoichiometric ratio, i.e., Zn-1/FBcCyD.…”

Section: Resultsmentioning

confidence: 99%

Selective ATP recognition by boronic acid-appended cyclodextrin and a fluorescent probe supramolecular complex in water

et al. 2023

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“…To improve the solubility, stability, and bioavailability of FA, β-CD complex in water has been investigated using electrospray ionization mass spectrometry, isothermal titration calorimetry (ITC), and nuclear magnetic resonance spectrometry [17]. Circular dichroism spectroscopy [18], fluorescence spectroscopy [19][20][21], ITC [22,23], and molecular docking simulation [24][25][26] have been used to study interactions between CDs and other drug molecules. It is noted that the in-depth characterization of CD-drug complexes for drug development is improved by developing new analytical tools.…”

Section: Introductionmentioning

confidence: 99%

β‐Cyclodextrin and folic acid host–guest interaction binding parameters determined by Taylor dispersion analysis and affinity capillary electrophoresis

et al. 2023

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The thermodynamic properties of molecular recognition in host-guest inclusion complexes can be studied by Taylor dispersion analysis (TDA). Host-guest inclusion complexes have modest size, and it is possible to get convergent results fast, achieving greater certainty for the obtained thermodynamic properties.Cyclodextrins (CDs) and their derivatives can be used as drug carriers that can boost stability, solubility, and bioavailability of physiologically active substances.A simple and effective approach for assessing the binding properties of CD complexes that are critical in the early stages of drug and formulation development is needed to fully understand the process of CD and guest molecules' complex formation. In this work, TDA was successfully used to rapidly determine interaction parameters, including binding constant and stoichiometry, between β-CD and folic acid (FA) along with the diffusivities of the free FA and its complex with β-CD. Additionally, the FA diffusion coefficient obtained by TDA was compared to the results previously obtained by nuclear magnetic resonance. Affinity capillary electrophoresis (ACE) was also used to compare the binding constants obtained by different methods. The results showed that the binding constants obtained by ACE were somewhat lower than those obtained by the two TDA procedures.

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Enhanced Characterization of Pyrene Binding in Mixed Cyclodextrin Systems via Fluorescence Spectroscopy

Cited by 10 publications

References 37 publications

Physicochemical Changes of Alginate and Polyacrylate Mixture Induced by Interactions of the Appended Units

Physicochemical Changes of Alginate and Polyacrylate Mixture Induced by Interactions of the Appended Units

Selective ATP recognition by boronic acid-appended cyclodextrin and a fluorescent probe supramolecular complex in water

β‐Cyclodextrin and folic acid host–guest interaction binding parameters determined by Taylor dispersion analysis and affinity capillary electrophoresis

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