Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

Peng, Shan; Wang, Yahua; Li, Na; Li, Chong

doi:10.1039/c7cc05894b

Cited by 36 publications

(30 citation statements)

References 30 publications

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“…Ligand-mediated target drug delivery strategy could provide improvements in various characteristics including permeation across physiologic barriers 81 , penetration into target sites 82 , internalization by target cells 83 , and specific subcellular locations 84 , etc. Originating from this strategy, the antibody–drug conjugate (ADC) has seen several marketed products, such as brentuximab vedotin 85 , gemtuzumab ozogamicin 86 and trastuzumab emtansine 87 , demonstrating the scientific significance and clinical value of ligand-mediated targeting.…”

Section: Emerging Strategies For Drug Deliverymentioning

confidence: 99%

Recent progress in drug delivery

Wang

et al. 2019

Acta Pharmaceutica Sinica B

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568

272

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Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015–2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.

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Section: Emerging Strategies For Drug Deliverymentioning

confidence: 99%

Recent progress in drug delivery

Wang

et al. 2019

Acta Pharmaceutica Sinica B

Self Cite

568

272

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“…The nanoMIP specifically targeted FRα‐overexpressing HeLa cells without being affected by the natural ligand, folate, in vitro and in vivo (Figure 3 B). Apart from the extracellular domain, the transmembrane domain with the α‐helix structure of FN14 was also chosen as the imprinting template to synthesize nanoMIP [29] . The prepared nanoMIP exhibited specific binding to template peptide, which induced greater cell endocytosis and superior tumor penetration capability in FN14‐positive tumors.…”

Section: Active Targeting Of Tumor Cellsmentioning

confidence: 99%

Molecularly Imprinted Polymer Nanoparticles: An Emerging Versatile Platform for Cancer Therapy

2020

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Molecularly imprinted polymers (MIPs) are chemically synthesized affinity materials with tailor‐made binding cavities complementary to the template molecules in shape, size, and functionality. Recently, engineering MIP‐based nanomedicines to improve cancer therapy has become a rapidly growing field and future research direction. Because of the unique properties and functions of MIPs, MIP‐based nanoparticles (nanoMIPs) are not only alternatives to current nanomaterials for cancer therapy, but also hold the potential to fill gaps associated with biological ligand‐based nanomedicines, such as immunogenicity, stability, applicability, and economic viability. Here, we survey recent advances in the design and fabrication of nanoMIPs for cancer therapy and highlight their distinct features. In addition, how to use these features to achieve desired performance, including extended circulation, active targeting, controlled drug release and anti‐tumor efficacy, is discussed and summarized. We expect that this minireview will inspire more advanced studies in MIP‐based nanomedicines for cancer therapy.

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“…Nevertheless, the untargeted delivery remains to be one major drawback of currently available SLN based DDSs that requires further efforts [13,14]. To address this issue, the integration of corresponding targeting ligands into the DDS has been adopted [15,16]. In the past decades, targeting ligands varying from small molecules to monoclonal antibodies have been successfully integrated into DDS to improve its tumour targeting capabilities [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Photothermal therapy (PTT) is a rapidly developing approach for cancer therapy, which has been widely recognized to exert high efficacy as compared to chemotherapy. However, the limited tumour homing property of currently available drug delivery systems (DDSs) is the bottleneck for the efficient delivery of photothermal agents. Here in this study, we surface modified silica nanoparticles (SLN) with the cell membrane (CM) derived from 143B cells to construct a platform (CM/SLN) capable of targeting the homogenous 143B cells. In addition, indocyanine green (ICG) as a photothermal agent was encapsulated into CM/SLN to finally construct a DDS suitable for tumour-targeted PTT of osteosarcoma. Our results revealed that CM/SLN/ICG was mono-dispersed core-shell nanoparticles with advanced stability in a physiological environment. Moreover, due to the modification of CM, CM/SLN/ICG could specifically target the homogenous 143B cells both in vitro and in vivo, which demonstrated superior anticancer efficacy when compared with either SLN/ICG or free ICG. Hence, CM/SLN/ICG could be a promising DDS for tumour targeted PTT of osteosarcoma.

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Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

Cited by 36 publications

References 30 publications

Recent progress in drug delivery

Recent progress in drug delivery

Molecularly Imprinted Polymer Nanoparticles: An Emerging Versatile Platform for Cancer Therapy

Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

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