2010
DOI: 10.1038/mi.2010.18
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Enhanced cellular responses and environmental sampling within inner foreskin explants: implications for the foreskin's role in HIV transmission

Abstract: The decrease in HIV acquisition after circumcision suggests a role for the foreskin in HIV transmission. However, the mechanism leading to protection remains undefined. Using tissue explant cultures we found that Langerhans cells (LCs) in foreskin alter their cellular protein expression in response to external stimuli. Furthermore, we observe that upon treatment with TNF-α, tissue-resident LCs became activated and that stimulatory cytokines can specifically cause an influx of CD4+ T-cells into the epithelial l… Show more

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Cited by 47 publications
(50 citation statements)
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“…DCs have been proposed to play an important role in HIV-1 transmission, because they are located in the mucosa (39,40), capture viruses using lectins (41,42) and glycosphingolipid receptors (43), and efficiently transmit infectious particles to CD4+ T cells (44)(45)(46). To examine whether TF and CC viruses differ in their ability to bind DCs, we pulsed immature monocyte-derived DCs (moDCs) with equal amounts of virus (normalized by RT activity), washed the cells extensively to remove cell-free virions, and then lysed the cells to quantify the amount of cell-associated virus.…”
Section: Resultsmentioning
confidence: 99%
“…DCs have been proposed to play an important role in HIV-1 transmission, because they are located in the mucosa (39,40), capture viruses using lectins (41,42) and glycosphingolipid receptors (43), and efficiently transmit infectious particles to CD4+ T cells (44)(45)(46). To examine whether TF and CC viruses differ in their ability to bind DCs, we pulsed immature monocyte-derived DCs (moDCs) with equal amounts of virus (normalized by RT activity), washed the cells extensively to remove cell-free virions, and then lysed the cells to quantify the amount of cell-associated virus.…”
Section: Resultsmentioning
confidence: 99%
“…Most studies have focused on transmission across the female genital mucosa, whereas mechanisms of HIV transmission across penile tissue are much less well understood, and are subject to ongoing research [11][12][13][14][15][16][17][18][19].…”
Section: Reviews In Medical Virologymentioning
confidence: 99%
“…Sexual HIV transmission is an inefficient process during which a limited number of virions initiate an infection in a new host, resulting in a severe transmission bottleneck [15,16]. Although CD4 + T cells are the predominant target cells of HIV, it has been postulated that dendritic cells (DCs) naturally residing in the genital mucosa play a major role during sexual transmission [17][18][19][20]. Within the genital mucosa, Langerhans cells (LCs) reside in the epithelial layer and are the first DC subset encountered by HIV.…”
Section: Introductionmentioning
confidence: 99%