Enhanced cell viscosity: A new phenotype associated with lamin A/C alterations

Deformation under flow and morphological recovery of cancer cells

“…The circle arc shape of the constriction, in contrast to long and uniform deformation channels developed in ref. 20,and 36–38, involves complex deformation and friction force patterns whose exact modelisation is outside the scope of this study. However, temporal monitoring of cell deformation in these constrictions may still provide useful comparisons between cell lines.…”

“…It should be noted that, due to the double flared shape of our constriction and its short length (relative to the cell diameter), this arrest time differs from the entry or the transit time as defined in the literature for funnel-shaped constrictions opening into a long and narrow channel. 20,36–38 Actually, our arrest time is a combination of both, reflecting the fact that cells are never arrested in the constriction but move slowly until their velocity displays an abrupt change upon cell release.…”