Enhanced cell growth on nanotextured GaN surface treated by UV illumination and fibronectin adsorption

Li, Jingying; Han, Qing; Wang, Xinhuan; Yang, Rong; Wang, Chen

doi:10.1016/j.colsurfb.2014.09.030

Cited by 12 publications

(13 citation statements)

References 45 publications

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“…The multifunctional 3D nanostructured GaN platform for cell capture was prepared as shown in Figure . First, we synthesized GaN nanowires using chemical vapor deposition method. − After that, we introduced a GaN binding peptide biotin-P1 onto the surfaces. Subsequently, biotinylated aptamer S2.2 was connected to bio-P1 through streptavidin.…”

Section: Resultsmentioning

confidence: 99%

“…It has excellent optical and electrical properties, − good chemical stability, and biocompatibility. − GaN-based biosensors have been used for detection of antibodies of different cancers, , action potentials of cardiac cells, and sodium flux of neuronal cells, etc. In previous work we reported that GaN nanowires could be used to regulate protein-adsorption and cell-adhesion by topography modification and UV-light irradiation. − …”

Section: Introductionmentioning

confidence: 99%

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Cell-Capture and Release Platform Based on Peptide-Aptamer-Modified Nanowires

Lian

et al. 2016

ACS Appl. Mater. Interfaces

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Nanowires have attracted much attention due to their potential bioapplications, such as delivery of drugs or sensing devices. Here we report the development of a unique cell-capture and release platform based on nanowires. The combination of nanowires, surface-binding peptides, and cell-targeting aptamers leads to specific and efficient capture of cancer cells. Moreover, the binding processes are reversible, which is not only useful for downstream analysis but also for reusability of the substrate. Our work provides a new method in the design of the cell-capture and release platform, which may open up new opportunities of developing cell-separation and diagnosis systems based on cell-capture techniques.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cell-Capture and Release Platform Based on Peptide-Aptamer-Modified Nanowires

Lian

et al. 2016

ACS Appl. Mater. Interfaces

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“…As we know, UV irradiation will produce electron-hole pairs in semiconductor materials such as gallium nitride (GaN), [33][34][35] …”

Section: View Article Onlinementioning

confidence: 99%

Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells

Zhou

Wang

Heng

et al. 2015

Phys. Chem. Chem. Phys.

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Today cancer is one of the most life-threatening diseases in the world. The conventional cancer therapies, including surgery, chemo- and radiation therapies, have some disadvantages, such as limited efficiency and significant side effects. It is necessary to develop new therapeutic treatments. Herein, we integrated the targeted photocatalytic and chemotherapy in a multifunctional drug-delivery platform. The aptamer-functionalized ZnO nanoparticles (NPs) were successfully synthesized. The anti-cancer drug was loaded in the aptamer-ZnO NP system. In vitro cell cytotoxicity experiments showed that combined therapy had a higher rate of death of cancer cells compared to that of single photocatalytic or chemotherapy. Furthermore, aptamer-functionalization could greatly increase the accumulation of nanoparticles within cancer cells and lead to better therapeutic effects. The results suggest that aptamer-functionalized semiconductor nanoparticles may have potential in the development of targeted photocatalytic and chemotherapy against cancer.

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“…[161,162] Recent work has provided considerable evidence that these III-V semiconductor materials such as GaN/ AlGaN, interface with bacteria and yeast and have great potential applications in biosensing and bioelectronics. [43,94,147,163] Moreover, certain works like an article by Li et al [164] discuss how the surface properties (texture and particle arrangement) of materials like GaN under various surface treatments may potentially alter cellular attachment onto the substrate surfaces. Lastly, work with semiconducting materials such as silicon (Si) [111,150,151] has provided information on their biocompatibility, adhesion profiles, and bactericidal capabilities.…”

Section: Inorganic Materials Interacting With Microorganismsmentioning

confidence: 99%