Enhanced cell cycle progression and down regulation of p21Cip1/Waf1 by PRL tyrosine phosphatases

Werner, Sean R.; Lee, Paul A.; DeCamp, Matthew; Crowell, Dring N.; Randall, Stephen K.; Crowell, Pamela L.

doi:10.1016/s0304-3835(03)00517-2

Cited by 77 publications

(86 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is possible that all three PRLs have functional redundancy. To investigate the functions of PRL-2 in lung cancer, we first performed p21-promoter reporter assay because it is well known that PRLs induce cell proliferation and malignant transformation through down-regulation of p21 (15). In p21-promoter luciferase reporter assay, all PRLs decreased the activity of p21 promoter.…”

Section: Discussionmentioning

confidence: 99%

“…Those effects are mediated through several signaling pathways such as PI3K/Akt, Rho GTPase, cyclin-dependent kinase 2 (CDK2), angiotensin II and p53 signaling (9,(12)(13)(14)(15)19,23). The PI3K/Akt is an important signaling pathway in cell survival, and it is frequently activated in human cancers.…”

Section: Discussionmentioning

confidence: 99%

“…To determine functions of PRLs in primary lung cancer cells, we first performed p21-luciferase reporter assay, since it is known that PRLs regulate p21 (15). Thus, we performed reporter assay to investigate the effect of PRLs on the activity of p21 promoter using overexpression of PRLs in A549 human lung adenocarcinoma epithelial cell line.…”

Section: Increased Expression Of Prl-2 Protein In Lung Cancermentioning

confidence: 99%

“…Because of the controversies in primary lung cancer, we investigated the expression patterns and levels of PRL-1, -2 and -3 in primary lung cancer patients. In addition, since PRL-1 and -3 but not PRL-2 have been known to be involved in several oncogenic signaling pathways including PI3K/AKT, C-terminal Src kinase (Csk), Rho GTPases, cyclin-dependent kinase (CDK2), ERK, p53 and p21 (9,(12)(13)(14)(15), we examined the change of the oncogenic signals by overexpression of PRL-1, -2 and -3 in a cancer cell line.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Altered expression of phosphatase of regenerating liver gene family in non-small cell lung cancer

Lee

2011

Oncol Rep

View full text Add to dashboard Cite

Abstract. Protein tyrosine phophatases (PTPs) are implicated in the tumorigenesis and metastasis of human cancer. The phosphatase of regenerating liver (PRL) gene family, a subgroup of PTPs is also linked to these processes. In many solid cancers, high levels of PRL-3 expression are related with metastasis and poor prognosis. However, the expression patterns of PRL-1 and -2 have not been explored in lung cancer yet. Thus, we investigated the expression levels of PRL-1, -2 and -3 in the tissues of primary lung cancer patients. The protein expression levels of PRL-2, but not PRL-1 and -3 were increased in cancer tissues. However, there was no correlation between mRNA and protein expression levels of the PRLs. Reporter assays showed that PRLs suppressed the activity of the p21 promoter but promoted AP-1 activity. Furthermore, transfection of PRLs showed significantly increased cell proliferation. Therefore, these results suggest that PRL-2 plays an important role in lung cancer and can be a biomarker of lung cancer, substituting for the function of other PRLs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Increased Expression Of Prl-2 Protein In Lung Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Altered expression of phosphatase of regenerating liver gene family in non-small cell lung cancer

Lee

2011

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…22,44,45 Although AKT activation contributes to cell cycle regulation through E2F, cyclin D 46 and mdm2/p53, 47 a role for AKT in determining the nature of cell cycle arrest after FTI treatment has not been established, and the current report would argue against such a link. Alternative candidates for mediators of cell cycle arrest after FTI treatment include CENP-E and CENP-F 43,48 and the PDK phosphatases 49,50 all of which are farnesylated.…”

Section: Fti and Cell Cycle Arrestmentioning

confidence: 99%

Farnesyltransferase inhibition: Who are the aktors?

Bernhard

2004

Cancer Biology & Therapy

View full text Add to dashboard Cite

Sub‐Mol % Catalyst Loading and Ligand‐Acceleration in the Copper‐Catalyzed Coupling of Aryl Iodides and Terminal Alkyenes

Zuidema

Bolm

2010

Chemistry A European J

View full text Add to dashboard Cite

show abstract

Enhanced cell cycle progression and down regulation of p21Cip1/Waf1 by PRL tyrosine phosphatases

Cited by 77 publications

References 41 publications

Altered expression of phosphatase of regenerating liver gene family in non-small cell lung cancer

Altered expression of phosphatase of regenerating liver gene family in non-small cell lung cancer

Farnesyltransferase inhibition: Who are the aktors?

Sub‐Mol % Catalyst Loading and Ligand‐Acceleration in the Copper‐Catalyzed Coupling of Aryl Iodides and Terminal Alkyenes

Contact Info

Product

Resources

About