Enhanced catalysis of ultrasmall Au-MoS 2 clusters against reactive oxygen species for radiation protection

Bian, Peixian; Zhang, Jinxuan; Wang, Junying; Yang, Jiang; Wang, Jingya; Liu, Haile; Sun, Yang; Li, Meixian; Zhang, Xiaodong

doi:10.1016/j.scib.2018.05.008

Cited by 29 publications

(17 citation statements)

References 66 publications

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“…Therefore, recently, some ultrasmall or ultrathin 2D nanomaterials such as WSe 2 , Bi 2 Se 3 , WS 2 , MoS 2 , and niobium carbide (MXene) with strong catalytic properties are developed for ROS scavenging in vitro and in vivo. [ 123–127 ] In a representative work, Zhang et al. designed ultrasmall cysteine‐functionalized MoS 2 quantum dots (sub‐5 nm) with strong catalytic performance as radioprotectants to investigate their protective effect in ionizing radiation (IR) ( Figure ).…”

Section: Ros‐associated Nanomedicines For Disease Treatmentsmentioning

confidence: 99%

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

et al. 2020

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Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving the topics in ROS‐regulating therapy such as antioxidant therapy triggered by ROS scavengers and ROS‐induced toxic therapy mediated by ROS‐elevation agents. Benefiting from the remarkable advances of nanotechnology, a large number of nanomaterials with the ROS‐regulating ability are developed to seek new and effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements have been made in ROS‐based nanomedicines for disease treatments, some fundamental but key questions such as the rational design principle for ROS‐related nanomaterials are held in low regard. Here, the design principle can serve as the initial framework for scientists and technicians to design and optimize the ROS‐regulating nanomedicines, thereby minimizing the gap of nanomedicines for biomedical application during the design stage. Herein, an overview of the current progress of ROS‐associated nanomedicines in disease treatments is summarized. And then, by particularly addressing these known strategies in ROS‐associated therapy, several fundamental and key principles for the design of ROS‐associated nanomedicines are presented. Finally, future perspectives are also discussed in depth for the development of ROS‐associated nanomedicines.

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Section: Ros‐associated Nanomedicines For Disease Treatmentsmentioning

confidence: 99%

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

et al. 2020

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“…In a previous review, we introduced many nanoradioprotectors. Thereafter, new nanoradioprotectors, such as ultrasmall Au‐MoS 2 clusters, [ 177 ] PVP‐coated PtPdMo nanocubes, [ 178 ] PtPd nanocrystals, [ 179 ] naturally derived PHA‐L protein NPs, [ 180 ] CeO 2 /Mn 3 O 4 nanocrystals, [ 57 ] pH‐triggered Mn clusters, [ 181 ] polydopamine@arginine–chitosan (thalidomide) nanodrugs, [ 58 ] Nb 2 C‐PVP nanosheets, [ 31 ] CNSI, [ 32 ] and the GLSO@P188/PEG400 nanosystem, [ 37 ] have emerged. Their emergence enriched the treatment pattern in the radioprotection field.…”

Section: Discussionmentioning

confidence: 99%

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

Xie

Zhao

Wang

et al. 2021

Adv Healthcare Materials

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Radiation treatments often unfavorably damage neighboring healthy organs and cause a series of radiation sequelae, such as radiation‐induced hematopoietic system diseases, radiation‐induced gastrointestinal diseases, radiation‐induced lung diseases, and radiation‐induced skin diseases. Recently, emerging nanomaterials have exhibited good superiority for these radiation‐induced disease treatments. Given this background, the rational design principle of nanomaterials, which helps to optimize the therapeutic efficiency, has been an increasing need. Consequently, it is of great significance to perform a systematic summarization of the advances in this field, which can trigger the development of new high‐performance nanoradioprotectors with drug efficiency maximization. Herein, this review highlights the advances and perspectives in the rational design of nanomaterials for preventing and treating various common radiation‐induced diseases. Furthermore, the sources, clinical symptoms, and pathogenesis/injury mechanisms of these radiation‐induced diseases will also be introduced. Furthermore, current challenges and directions for future efforts in this field are also discussed.

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“…Transition metal chalcogenides have shown great potential in biological systems due to their tunable electronic characteristics, unique optical properties, and excellent catalytic activities. − The ultrasmall Au-MoS 2 clusters prepared by Bian et al exhibited stronger catalytic properties than MoS 2 . Due to the synergistic effect of Au and MoS 2 , the catalytic performance of the clusters was improved and the active sites were increased, which can effectively enhance the corresponding activity to scavenge free radicals caused by irradiation.…”

Section: Catalytic Nanozyme For Radiation Protectionmentioning

confidence: 99%

Catalytic Nanozyme for Radiation Protection

Zhao

Liu

et al. 2021

Bioconjugate Chem.

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Radiotherapy has been widely used in clinical cancer treatment. However, the ionizing radiation required to kill the tumor will inevitably cause damage to the surrounding normal tissues. To minimize the radiation damage and side effects, small molecular radioprotective agents have been used as clinical adjuvants for radiation protection of healthy tissues. However, the shortcomings of small molecules such as short circulation time and rapid kidney clearance from the body greatly hinder their biomedical applications. In recent years, nanozymes have attracted much attention because of their potential to treat a variety of diseases. Nanozymes exhibit catalytic properties and antioxidant capabilities to provide a potential solution for the development of high-efficiency radioprotective agents in radiotherapy and nuclear radiation accidents. Therefore, in this review, we systematically summarize the catalytic nanozymes used for radiation protection of healthy tissues and discuss the challenges and future prospects of nanomaterials in the field of radiation protection.

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Enhanced catalysis of ultrasmall Au-MoS 2 clusters against reactive oxygen species for radiation protection

Cited by 29 publications

References 66 publications

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

Catalytic Nanozyme for Radiation Protection

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