Enhanced bone tissue regeneration via bioactive electrospun fibrous composite coated titanium orthopedic implant

Song, Qichun; Prabakaran, Selvakani; Duan, Jiafeng; Jeyaraj, Murugaraj; Mickymaray, Suresh; Paramasivam, Anand; Rajan, Mariappan

doi:10.1016/j.ijpharm.2021.120961

Cited by 12 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bioactive factors could also be incorporated into scaffolds through intermolecular hydrogen bonding, affinity interaction, etc. Song et al ( Song et al, 2021 ) developed a nanofibrous composite-coated titanium implant via electrospinning to enhance bone regeneration. They prepared the electrospun fiber composites using minerals (Zn, Mg, Si) substituted hydroxyapatite (MHAP), Polyethylene Glycol (PEG)/Cissus quadrangularis (CQ) extract.…”

Section: The Mechanism Of Bioactive Factors On Slow-release Systemmentioning

confidence: 99%

Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair

Pei,

Hu,

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

In recent years, bone tissue engineering (BTE) has played an essential role in the repair of bone tissue defects. Although bioactive factors as one component of BTE have great potential to effectively promote cell differentiation and bone regeneration, they are usually not used alone due to their short effective half-lives, high concentrations, etc. The release rate of bioactive factors could be controlled by loading them into scaffolds, and the scaffold microstructure has been shown to significantly influence release rates of bioactive factors. Therefore, this review attempted to investigate how the scaffold microstructure affected the release rate of bioactive factors, in which the variables included pore size, pore shape and porosity. The loading nature and the releasing mechanism of bioactive factors were also summarized. The main conclusions were achieved as follows: i) The pore shapes in the scaffold may have had no apparent effect on the release of bioactive factors but significantly affected mechanical properties of the scaffolds; ii) The pore size of about 400 μm in the scaffold may be more conducive to controlling the release of bioactive factors to promote bone formation; iii) The porosity of scaffolds may be positively correlated with the release rate, and the porosity of 70%–80% may be better to control the release rate. This review indicates that a slow-release system with proper scaffold microstructure control could be a tremendous inspiration for developing new treatment strategies for bone disease. It is anticipated to eventually be developed into clinical applications to tackle treatment-related issues effectively.

show abstract

Section: The Mechanism Of Bioactive Factors On Slow-release Systemmentioning

confidence: 99%

Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair

Pei,

Hu,

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Electrospinning is a simple and widely used technique for producing nanofibers for application in tissue engineering ( Han et al, 2021 ; Sensini et al, 2021a ; Song et al, 2021 ). The electrospinning device is so simple that it can be used in almost any laboratory.…”

Section: Nanofiber-based Scaffoldsmentioning

confidence: 99%

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Zhu

He²,

Ji³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.

show abstract

“…In this study, hydroxyapatite (HAP) bone renewing material facilitates higher bone renewing ability and involves higher resorption (Bharati et al, 2005;Song et al, 2021). In 2021, Fu et al reviewed the HAP-based polyester composites for bone regeneration applications (Fu et al, 2021).…”

Section: Introductionmentioning

confidence: 98%

Hydroxyapatite-collagen- carboxylic carbon quantum dot composite loaded with chrysin supported the proliferation and differentiation of human bone marrow derived mesenchymal stem cells

Zhou

Chen²,

Mickymaray³

et al. 2022

Front. Mater.

View full text Add to dashboard Cite

Developing a bioactive scaffold with biocompatible material is a substantial approach to bone regeneration and functional healing. Hydroxyapatite (HAP) is the main component in bone formation as an inorganic component and regeneration due to its osteoconductive properties. In this study, we prepared a scaffold material composed of HAP and collagen (COL) cross-linked via carboxylic carbon quantum dots (CCQD) with a chrysin (CRN) molecule. CRN is a flavonoid that has been shown to encourage the bone development of bone marrow-derived mesenchymal stem cells. It is loaded for enhancing bone regeneration and HAP’s growth ability. XRD, FT-IR, SEM, and TEM analysis have characterized the prepared composites for their crystalline nature, functional behavior, and morphological evaluations. The HAP has retained its original crystalline lattice confirmed from XRD analysis in the prepared composites. The addition of CRN molecule has decreased the length of HAP rods from ∼932 nm to ∼459 nm, as confirmed by TEM images. The increased particle sizes have been observed for the prepared composites. It reaches the maximum at 938.0 nm for the final HAP/COL/CCQD/CRN composite, which was confirmed by particle size analysis. The in-vitro CRN release behavior shows that the CRN molecule has controlled release up to 23% for 48 h. The biocompatibility of prepared material was investigated and confirmed on human bone marrow-derived mesenchymal stem cells (hBMSCs). This examination has proven that the prepared material is good for bone cell regeneration. The material may apply for bone regeneration applications after in-vivo and clinical investigations.

show abstract

Enhanced bone tissue regeneration via bioactive electrospun fibrous composite coated titanium orthopedic implant

Cited by 12 publications

References 46 publications

Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair

Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Hydroxyapatite-collagen- carboxylic carbon quantum dot composite loaded with chrysin supported the proliferation and differentiation of human bone marrow derived mesenchymal stem cells

Contact Info

Product

Resources

About