Enhanced bone tissue regeneration using a 3D-printed poly(lactic acid)/Ti6Al4V composite scaffold with plasma treatment modification

Zarei, Masoud; Dargah, Motahareh Shabani; Azar, Mahdi Hasanzadeh; Alizadeh, Reza; Mahdavi, Fatemeh Sadat; Sayedain, Sayed Shahab; Kaviani, Alireza; Asadollahi, Mohammad; Azami, Mahmoud; Beheshtizadeh, Nima

doi:10.1038/s41598-023-30300-z

Cited by 34 publications

(32 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reproduced with permission. [98] Copyright 2023, Springer Nature. b) Fabrication of a soft somatosensory actuator (SSA) innervated by several soft sensors depending on the shear stress for sensor inks consisting of 1-ethyl-3-methylimidazolium ethyl sulfate with different contents of colloidal silica (wt.%).…”

Section: Mechanical Properties Of Lubricating Polymer Compositionsmentioning

confidence: 99%

Additive Manufacturing of Polymer‐Based Lubrication

Hossain

Jiang

Yao

et al. 2023

Macro Materials & Eng

View full text Add to dashboard Cite

The fast growth of 3D printing technology gives designers many ways to make structures that are hard to see. 3D printing lets you customize complex structures in any way you want and make rapid prototypes of materials. It enables you to simulate things more effectively. So far, experiments with polymer‐based lubrication have been done on atomically smooth surfaces, under dynamic conditions, and on the nano‐ or micro‐scale. Polymer‐based lubrication in 3D printing has been studied in depth, which has made it possible to make significant, multifunctional 3D structures with microscale accuracy. It is a crucial way to approach lubrication and has sparked much scientific interest. A thorough literature review is done to keep track of the latest advances in 3D printing for structural polymer‐based lubrication simulation. The design and lubrication performance quality of bio‐inspired, different‐sized simulation structures is given much attention. The material requirements, skills, and representative applications of various 3D printing technologies are summarized. The efficient directions for future research in designing and making 3D‐printed lubrication structures are also pointed out.

show abstract

Section: Mechanical Properties Of Lubricating Polymer Compositionsmentioning

confidence: 99%

Additive Manufacturing of Polymer‐Based Lubrication

Hossain

Jiang

Yao

et al. 2023

Macro Materials & Eng

View full text Add to dashboard Cite

show abstract

“…The accuracy of the developed models was evaluated with the testing data set presented in Table 9. For each TPMS performance (e.g., E, σ peak , and SEA), the accuracy of the developed ANFIS models was evaluated using the mean absolute percentage error (MAPE), which was calculated using Equation (6).…”

Section: Mathematical and Anfis Prediction Modelsmentioning

confidence: 99%

“…In regards to material, AM allows for controlling material composition, e.g., incorporating particles/fibers as reinforcement, leading to uncovering new enhanced multiphase (composite) materials. This enhances the functionality and performance of the lattices in many aspects, such as mechanical [ 3 , 4 , 5 , 6 ], medical [ 6 , 7 ], electrical [ 8 ], and multifunctional characteristics [ 9 ]. In this regard, the FDM technique offers promising potential for developing highly reliable and mechanically strong composite lattice structures [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Regarding the incorporation of reinforcements as a strategy for enhancing lattices’ performance, very limited work has been reported particularly in TPMS structures. Zarei Zarei et al [ 6 ] explored the effect of adding Ti6Al4V to PLA on the mechanical and biological performance of FDM-printed scaffolds. The results demonstrated that the ultimate compressive strength and compressive modulus of composite scaffolds were enhanced by the incorporation of 3–6 wt% Ti6Al4V.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prediction of Mechanical Properties for Carbon fiber/PLA Composite Lattice Structures Using Mathematical and ANFIS Models

et al. 2023

View full text Add to dashboard Cite

This study investigates the influence of design, relative density (RD), and carbon fiber (CF) incorporation parameters on mechanical characteristics, including compressive modulus (E), strength, and specific energy absorption (SEA) of triply periodic minimum surface (TPMS) lattice structures. The TPMS lattices were 3D-printed by fused filament fabrication (FFF) using polylactic acid (PLA) and carbon fiber-reinforced PLA(CFRPLA). The mechanical properties of the TPMS lattice structures were evaluated under uniaxial compression testing based on the design of experiments (DOE) approach, namely, full factorial design. Prediction modeling was conducted and compared using mathematical and intelligent modeling, namely, adaptive neuro-fuzzy inference systems (ANFIS). ANFIS modeling allowed the 3D printing imperfections (e.g., RD variations) to be taken into account by considering the actual RDs instead of the designed ones, as in the case of mathematical modeling. In this regard, this was the first time the ANFIS modeling utilized the actual RDs. The desirability approach was applied for multi-objective optimization. The mechanical properties were found to be significantly influenced by cell type, cell size, CF incorporation, and RD, as well as their combination. The findings demonstrated a variation in the E (0.144 GPa to 0.549 GPa), compressive strength (4.583 MPa to 15.768 MPa), and SEA (3.759 J/g to 15.591 J/g) due to the effect of the studied variables. The ANFIS models outperformed mathematical models in predicting all mechanical characteristics, including E, strength, and SEA. For instance, the maximum absolute percent deviation was 7.61% for ANFIS prediction, while it was 21.11% for mathematical prediction. The accuracy of mathematical predictions is highly influenced by the degree of RD deviation: a higher deviation in RD indicates a lower accuracy of predictions. The findings of this study provide a prior prediction of the mechanical behavior of PLA and CFRPLA TPMS structures, as well as a better understanding of their potential and limitations.

show abstract

“…In this respect, cold atmospheric plasma, carried out in the presence of helium, was previously assessed as a modification tool for PLA scaffolds to evaluate osteoblast and mesenchymal stem cell attachment [ 29 ]. The effects of the treatment have been also considered to modify PLA-Ti6Al4V composites with oxygen or air, the latter providing better mechanical and bioactivity properties [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Physiologic Response Evaluation of Human Foetal Osteoblast Cells within Engineered 3D-Printed Polylactic Acid Scaffolds

Rizzo

Palermo

Alibrandi

et al. 2023

Biology

View full text Add to dashboard Cite

Large bone defect treatments have always been one of the important challenges in clinical practice and created a huge demand for more efficacious regenerative approaches. The bone tissue engineering (BTE) approach offered a new alternative to conventional bone grafts, addressing all clinical needs. Over the past years, BTE research is focused on the study and realisation of new biomaterials, including 3D-printed supports to improve mechanical, structural and biological properties. Among these, polylactic acid (PLA) scaffolds have been considered the most promising biomaterials due to their good biocompatibility, non-toxic biodegradability and bioresorbability. In this work, we evaluated the physiological response of human foetal osteoblast cells (hFOB), in terms of cell proliferation and osteogenic differentiation, within oxygen plasma treated 3D-printed PLA scaffolds, obtained by fused deposition modelling (FDM). A mechanical simulation to predict their behaviour to traction, flexural or torque solicitations was performed. We found that: 1. hFOB cells adhere and grow on scaffold surfaces; 2. hFOB grown on oxygen plasma treated PLA scaffolds (PLA_PT) show an improvement of cell adhesion and proliferation, compared to not-plasma treated scaffolds (PLA_NT); 3. Over time, hFOB penetrate along strands, differentiate, and form a fibrous matrix, tissue-like; 4. 3D-printed PLA scaffolds have good mechanical behaviour in each analysed configuration. These findings suggest that 3D-printed PLA scaffolds could represent promising biomaterials for medical implantable devices in the orthopaedic field.

show abstract

Enhanced bone tissue regeneration using a 3D-printed poly(lactic acid)/Ti6Al4V composite scaffold with plasma treatment modification

Cited by 34 publications

References 92 publications

Additive Manufacturing of Polymer‐Based Lubrication

Additive Manufacturing of Polymer‐Based Lubrication

Prediction of Mechanical Properties for Carbon fiber/PLA Composite Lattice Structures Using Mathematical and ANFIS Models

Physiologic Response Evaluation of Human Foetal Osteoblast Cells within Engineered 3D-Printed Polylactic Acid Scaffolds

Contact Info

Product

Resources

About