Enhanced bone regeneration with a gold nanoparticle–hydrogel complex

Heo, Dong Nyoung; Ko, Wan‐Kyu; Bae, Min Soo; Lee, Jung Bok; Lee, Deok-Won; Byun, Wook; Lee, Chang Hoon; Kim, Eun-Cheol; Jung, Bock-Young; Kwon, Il Keun

doi:10.1039/c3tb21246g

Cited by 240 publications

(176 citation statements)

References 38 publications

(50 reference statements)

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“…68 Biodegradable gelatin hydrogel incorporating gold nanoparticles (average size 27±3 nm) was also studied. 70 The results showed that these gel-gold nanoparticles were degradable with collagenase and promoted significant alkaline phosphatase activity, proliferation, viability, and osteogenic differentiation of stem cells. Moreover, the gel-gold nanoparticles achieved significantly greater new bone formation in vivo, indicating its potential for treating fractured bones.…”

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confidence: 91%

Nanotechnology for treating osteoporotic vertebral fractures

Gao¹,

Wei²,

Yang³

et al. 2015

IJN

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Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided.

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mentioning

confidence: 91%

Nanotechnology for treating osteoporotic vertebral fractures

Gao¹,

Wei²,

Yang³

et al. 2015

IJN

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“…It is then followed by proliferation, differentiation, and matrix formation [173]. Generally, bone tissue engineering materials requires high mechanical strength of osteoconductive characteristics [174]. However, hydrogel has a low mechanical strength and needs to improve its mechanical properties to mimic bone tissue.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Min¹,

Koh²

2018

Preprint

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In the field of tissue engineering, conductive hydrogels have been the most effective biomaterials to mimic the biological and electrical properties of tissues in the human body. The main advantages of conductive hydrogel include not only its physical properties, but also its adequate electrical properties, thus providing electrical signals to cells efficiently. However, when introducing a conductive material into a non-conductive hydrogel, a conflicting relationship between the electrical and mechanical properties may develop. This review examines the strengths and weaknesses of the generation of conductive hydrogels using various conductive materials and introduces the use of these conductive hydrogels in tissue engineering applications.

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“…7 Nanoparçacıkların kemikteki kullanım alanlarının başında rejeneratif tedavide hücre işa-retleyici, kanser ve diğer kemik hastalıklarında ilaç taşıyıcı ve gen taşıyıcı, kemik doku mühendisliğinde ise mineralizasyonu aktive etmek için kaplama ve dolgu maddesi olarak kullanımı gelmektedir. [7][8][9] Nanoparçacıkların günlük yaşamda kullanım-larına ilişkin çalışmaların artışına paralel olarak, bu parçacıkların insan ve çevre sağlığı üzerine etkilerine ilişkin araştırmalar da giderek artmaktadır. Doğal ortamda veya kullanılan ürünlerde bulunan nanoparçacıklar bulundukları ortamdan kolaylıkla ayrılarak havaya, havadan da solunum yoluyla vü-cuda geçmektedirler.…”

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Effects of Silica Nanoparticles on Rat Cortical Bone Biomechanics: Experimental Study

Çömelekoğlu¹,

Söğüt²,

Uzun³

et al. 2017

Turkiye Klinikleri J Lab Anim

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oyutu 1-100 nm aralığında yer alan parçacıklar "nanoparçacık" olarak adlandırılmaktadır. Nanoparçacıklar; elektron tutuculuğu, parçacık şekilleri, parçacık yüzey kimyası, ısı ve elektriksel iletkenlik, manyetik ve optik olmak üzere birçok fizikokimyasal özelliğe sahiptir. [1][2][3] Nanoparçacıkların etkileri boyutlarına bağlı olarak değişmektedir. Boyutları A An na ah ht ta ar r K Ke el li im me el le er r: : Nanopartiküller; biyomekanik; kırıklar, kemik A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Silica (SiO 2 ) nanoparticles are widely used in fields including agriculture, textile, electronics, cosmetic, painting industry and medicine. SiO 2 nanoparticles enter the body in different ways and have a toxic effect on the tissue and organs. In this study, the effect of SiO 2 nanoparticles were investigated on the bone biomechanics. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Fourteen 12-week-old Wistar albino male rats were divided randomly to a control (n=7) and experimental (n=7) groups. Animals in the experimental group were intraperitoneally administered at a dose of 150 μg/mL 6 nm sized SiO 2 nanoparticles for 28 days. The rats in the control group were given an equal volume of saline. Bone biomechanical parameters were measured in cortical femur with tensile testing machine and breaking force, deformation, energy, ultimate stress, ultimate strain, toughness and elastic modulus were calculated for all cortical femurs. R Re es su ul lt ts s: : In the experimental group, breaking force, energy, ultimate stress, and toughness were significantly lower than those of the control group (p<0.05). Deformation, ultimate strain and elastic modulus were not changed in experimental group when compared to control group (p>0.05). C Co on nc cl lu us si io on n: : The results of the present study indicate that the administration 150 μg/mL of 6 nm sized SiO 2 nanoparticles reduce of the biomechanical quality of the bone. This reduction may thought to increase the risk of fracture of cortical bone.

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Enhanced bone regeneration with a gold nanoparticle–hydrogel complex

Abstract: A hybrid hydrogel composed of gelatin and gold nanoparticles (GNPs) was designed to evaluate the effect of new bone formation and proves itself to be useful as an implant material for treating defected bone tissues.

Cited by 240 publications

References 38 publications

Nanotechnology for treating osteoporotic vertebral fractures

Nanotechnology for treating osteoporotic vertebral fractures

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Effects of Silica Nanoparticles on Rat Cortical Bone Biomechanics: Experimental Study

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