Enhanced bone regeneration via ZIF-8 decorated hierarchical polyvinylidene fluoride piezoelectric foam nanogenerator: Coupling of bioelectricity, angiogenesis, and osteogenesis

Chen, Junyu; Song, Li; Qi, Fangwei; Qin, Siyu; Yang, Xiangjun; Xie, Wenjia; Gai, Kuo; Han, Ying; Zhang, Xin; Zhu, Zunlue; Cai, He; Pei, Xibo; Wan, Qianbing; Chen, Ning; Wang, Jian; Wang, Qi; Li, Yijun

doi:10.1016/j.nanoen.2022.108076

Cited by 24 publications

(9 citation statements)

References 68 publications

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“…In addition, charges generated by the piezoelectric effect induce endogenous cell potentials and promote bone differentiation or regeneration. [ 50,51 ]…”

Section: Resultsmentioning

confidence: 99%

“…In addition, charges generated by the piezoelectric effect induce endogenous cell potentials and promote bone differentiation or regeneration. [50,51] The output voltage of the nanofibers generated via the piezoelectric effect was recorded separately (Figure 3F; Figure S6, Supporting Information). Under stable external force (0.5 N), the output voltage for sensitive nanofibers gradually increased from 0.12 to 0.94 V, for RA was 0.1 to 0.9 V at 100 °C and rapidly decreased when the temperature was higher than 110 °C.…”

Section: Piezoelectrical Properties Of Annealed Pvdf Filmsmentioning

confidence: 99%

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Stem Cell Self‐Triggered Regulation and Differentiation on Polyvinylidene Fluoride Electrospun Nanofibers

Wu,

Shi,

Zhou

et al. 2023

Adv Funct Materials

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Smart electroactive materials that can dynamically regulate stem cell fate without external stimuli have fascinated increasing attention. Meanwhile, noninvasive electrical stimulation has emerged as a less restrictive approach, generating considerable interest in its potential biomedical applications. The intricate interplay between cells and materials within complex microenvironments includes encompassing substrate response, ion exchange, and membrane potential alterations. However, the mechanisms by which smart materials influence stem cells have yet to be fully elucidated. Herein, electrospinning technology is utilized to fabricate bone‐mimicking microenvironments comprising disordered and highly oriented polyvinylidene fluoride (PVDF) nanofibers. The aligned annealed PVDF (AA) and random annealed PVDF (RA) membranes present high fractions of β‐phase. By comparing the osteogenic ability, calcium activity, and F‐actin distribution of bone marrow‐derived mesenchymal stem cells (BMSCs) cultured with these PVDF nanofibers, it is proposed that the stem cells autonomously regulate their differentiation by remodeling the cytoskeleton on the electrospun membranes. Electrical stimulation, more adhesion area, and active calcium influx support the greater osteogenesis of BMSCs on RA than AA. This mechanism can provide a basic theory for the design and preparation of bone tissue engineering scaffolds and contribute to the further study of cells and microenvironments.

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“…In addition, charges generated by the piezoelectric effect induce endogenous cell potentials and promote bone differentiation or regeneration. [ 50,51 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Piezoelectrical Properties Of Annealed Pvdf Filmsmentioning

confidence: 99%

Stem Cell Self‐Triggered Regulation and Differentiation on Polyvinylidene Fluoride Electrospun Nanofibers

Wu,

Shi,

Zhou

et al. 2023

Adv Funct Materials

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“…Chen et al successfully prepared a multistage PVDF foam and modified it with ZIF-8. 192 The relationship and synergistic effect between the piezoelectric effect of PVDF and the biological characteristics of ZIF-8 made the continuous release and enrichment of Zn 2+ , resulting in better biological effects.…”

Section: Multimodal Synergistic Antimicrobialsmentioning

confidence: 99%

Construction of antibacterial bone implants and their application in bone regeneration

Feng,

He,

et al. 2024

Mater. Horiz.

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“…Experiments proved that PVDF/ZIF-8 foam promoted in vitro angiogenic and osteogenic activity as well as antibacterial effects under piezoelectric conditions. 204 Besides, K Su et al have developed a fast photo-sonotherapy technique for the clinical treatment of bacterial infections in bone implants. This approach involves the creation of oxygen deficiency through sulfur doping (Fig.…”

Section: Artificial Biomaterialsmentioning

confidence: 99%

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

Han,

Xiong,

Jin

et al. 2024

J. Mater. Chem. B

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Enhanced bone regeneration via ZIF-8 decorated hierarchical polyvinylidene fluoride piezoelectric foam nanogenerator: Coupling of bioelectricity, angiogenesis, and osteogenesis

Cited by 24 publications

References 68 publications

Stem Cell Self‐Triggered Regulation and Differentiation on Polyvinylidene Fluoride Electrospun Nanofibers

Stem Cell Self‐Triggered Regulation and Differentiation on Polyvinylidene Fluoride Electrospun Nanofibers

Construction of antibacterial bone implants and their application in bone regeneration

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

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