Enhanced bone regeneration of 3D printed β-Ca2SiO4 scaffolds by aluminum ions solid solution

Yu, Bin; Fu, Shengyang; Kang, Zhanrong; Zhu, Min; Ding, Huifeng; Luo, Tao; Zhu, Yufang; Zhang, Yunting

doi:10.1016/j.ceramint.2019.11.282

Cited by 18 publications

(10 citation statements)

References 34 publications

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“…In several studies [ 43 , 75 , 76 , 77 , 78 , 79 , 80 ], Si was part of the native material, but not considered as a determining factor in the bone repair evaluated. Although Meseguer et al [ 78 ] only performed qualitative observations, all studies reported a bone repair enhancement.…”

Section: Resultsmentioning

confidence: 99%

In Vivo Application of Silica-Derived Inks for Bone Tissue Engineering: A 10-Year Systematic Review

et al. 2022

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As the need for efficient, sustainable, customizable, handy and affordable substitute materials for bone repair is critical, this systematic review aimed to assess the use and outcomes of silica-derived inks to promote in vivo bone regeneration. An algorithmic selection of articles was performed following the PRISMA guidelines and PICO method. After the initial selection, 51 articles were included. Silicon in ink formulations was mostly found to be in either the native material, but associated with a secondary role, or to be a crucial additive element used to dope an existing material. The inks and materials presented here were essentially extrusion-based 3D-printed (80%), and, overall, the most investigated animal model was the rabbit (65%) with a femoral defect (51%). Quality (ARRIVE 2.0) and risk of bias (SYRCLE) assessments outlined that although a large majority of ARRIVE items were “reported”, most risks of bias were left “unclear” due to a lack of precise information. Almost all studies, despite a broad range of strategies and formulations, reported their silica-derived material to improve bone regeneration. The rising number of publications over the past few years highlights Si as a leverage element for bone tissue engineering to closely consider in the future.

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Section: Resultsmentioning

confidence: 99%

In Vivo Application of Silica-Derived Inks for Bone Tissue Engineering: A 10-Year Systematic Review

et al. 2022

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“…Significantly higher proliferation and differentiation of rat BM-MSCs on the aluminum-modified scaffolds were observed; also, their degradation rate was slower. Enrichment with Al 2 O 3 exhibited enhanced bone formation, which has been proven by increased expression of osteogenic markers such as OC, OPN, and Col1 [162].…”

Section: Aluminum Oxide Nanoparticlesmentioning

confidence: 95%

Nanomaterials in Bone Regeneration

et al. 2022

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Nanomaterials are promising in the development of innovative therapeutic options that include tissue and organ replacement, as well as bone repair and regeneration. The expansion of new nanoscaled biomaterials is based on progress in the field of nanotechnologies, material sciences, and biomedicine. In recent decades, nanomaterial systems have bridged the line between the synthetic and natural worlds, leading to the emergence of a new science called nanomaterial design for biological applications. Nanomaterials replicating bone properties and providing unique functions help in bone tissue engineering. This review article is focused on nanomaterials utilized in or being explored for the purpose of bone repair and regeneration. After a brief overview of bone biology, including a description of bone cells, matrix, and development, nanostructured materials and different types of nanoparticles are discussed in detail.

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“…After sintering at 1200 °C, porous β-Ca 2 SiO 4 scaffolds with a well-interconnected pore of 400 μm, porosity of 78%, and compressive strength of 5.2 MPa were obtained . In another work, the strength of the β-Ca 2 SiO 4 scaffolds was improved by the introduction of Al ions . Pei et al prepared a mixture of mesoporous calcium silicate/calcium sulfate hemihydrate (MCS/CSH) in the ratios of 100:0, 80:20, and 60:40 and printed using a 3D bioplotter followed by a hydration process.…”

Section: Physical and Mechanical Characteristics Of Additive Manufact...mentioning

confidence: 99%

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

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This review focuses on the advancements in additive manufacturing techniques that are utilized for fabricating bioceramic scaffolds and their characterizations leading to bone tissue regeneration. Bioscaffolds are made by mimicking the human bone structure, material composition, and properties. Calcium phosphate apatite materials are the most commonly used scaffold materials as they closely resemble live bone in their inorganic composition. The functionally graded scaffolds are fabricated by utilizing the right choice of the 3D printing method and material combinations to achieve the requirement of the bioscaffold. To tailor the physical, mechanical, and biological properties of the scaffold, certain materials are reinforced, doped, or coated to incorporate the functionality. The biomechanical loading conditions that involve flexion, torsion, and tension exerted on the implanted scaffold are discussed. The finite element analysis (FEA) technique is used to investigate the mechanical property of the scaffold before fabrication. This helps in reducing the actual number of samples used for testing. The FEA simulated results and the experimental result are compared. This review also highlights some of the challenges associated while processing the scaffold such as shrinkage, mechanical instability, cytotoxicity, and printability. In the end, the new materials that are evolved for tissue engineering applications are compiled and discussed.

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Enhanced bone regeneration of 3D printed β-Ca2SiO4 scaffolds by aluminum ions solid solution

Cited by 18 publications

References 34 publications

In Vivo Application of Silica-Derived Inks for Bone Tissue Engineering: A 10-Year Systematic Review

In Vivo Application of Silica-Derived Inks for Bone Tissue Engineering: A 10-Year Systematic Review

Nanomaterials in Bone Regeneration

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

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