Enhanced biological properties of biomimetic apatite fabricated polycaprolactone/chitosan nanofibrous bio-composite for tendon and ligament regeneration

Wang, Geng; Deng, Xuefeng; Song, Jingyu; Chen, Feiqiang

doi:10.1016/j.jphotobiol.2017.10.011

Cited by 56 publications

(28 citation statements)

References 31 publications

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“…AM have been shown to contain growth factors such as platelet-derived growth factor (PDGF), transforming growth factor-a (TGF-a), TGF-b1, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), placental growth factor (PLGF) and granulocyte-colony stimulating factor (G-CSF) [82]. AM Mass production with low cost [180] PLLA High mechanical strength [181] Synthetic/natural PCL/CHT Combination of the best properties of both natural and synthetic polymers [182] PLCL/Collagen [102] PCL/CHT/HA [183] PLLA/CHT-collagen/ alginate [184] PCL polycaprolactone, PLGA poly (lactic-co-glycolic acid), CHT chitosan, PLCL poly (L-lactide-co-e-caprolactone), PLLA poly-L-lactic acid, HA hydroxyapatite possesses biological properties that have great significance in tissue engineering including anti-microbial, anti-inflammatory, anti-scarring, anti-fibrosis in addition to satisfactory mechanical property and low immunogenicity [83]. Decellularization technique is an important step for building the AM scaffold as this technique will reduce immunoreactivity from the host and create space for recellularization with target cells.…”

Section: Human Amniotic Membrane As a Scaffold For Tendon/ligament Timentioning

confidence: 99%

Current Progress in Tendon and Ligament Tissue Engineering

Lim

Liau

et al. 2019

Tissue Eng Regen Med

142

146

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BACKGROUND: Tendon and ligament injuries accounted for 30% of all musculoskeletal consultations with 4 million new incidences worldwide each year and thus imposed a significant burden to the society and the economy. Damaged tendon and ligament can severely affect the normal body movement and might lead to many complications if not treated promptly and adequately. Current conventional treatment through surgical repair and tissue graft are ineffective with a high rate of recurrence. METHODS: In this review, we first discussed the anatomy, physiology and pathophysiology of tendon and ligament injuries and its current treatment. Secondly, we explored the current role of tendon and ligament tissue engineering, describing its recent advances. After that, we also described stem cell and cell secreted product approaches in tendon and ligament injuries. Lastly, we examined the role of the bioreactor and mechanical loading in in vitro maturation of engineered tendon and ligament. RESULTS: Tissue engineering offers various alternative ways of treatment from biological tissue constructs to stem cell therapy and cell secreted products. Bioreactor with mechanical stimulation is instrumental in preparing mature engineered tendon and ligament substitutes in vitro. CONCLUSIONS: Tissue engineering showed great promise in replacing the damaged tendon and ligament. However, more study is needed to develop ideal engineered tendon and ligament.

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Section: Human Amniotic Membrane As a Scaffold For Tendon/ligament Timentioning

confidence: 99%

Current Progress in Tendon and Ligament Tissue Engineering

Lim

Liau

et al. 2019

Tissue Eng Regen Med

142

146

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“…Wu et al focused on the repair of the tendon-to-bone and ligament-to-bone insertions: they analyzed nanostructured HAp, loaded in random nanofibrous blends mats of PCL and CTS. They found increased osteoblast viability after 48 h of culture [ 109 ].…”

Section: Applications For Tendon and Ligament Regeneration And Repmentioning

confidence: 99%

Biofabrication of Electrospun Scaffolds for the Regeneration of Tendons and Ligaments

2018

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Tendon and ligament tissue regeneration and replacement are complex since scaffolds need to guarantee an adequate hierarchical structured morphology, and non-linear mechanical properties. Moreover, to guide the cells’ proliferation and tissue re-growth, scaffolds must provide a fibrous texture mimicking the typical of the arrangement of the collagen in the extracellular matrix of these tissues. Among the different techniques to produce scaffolds, electrospinning is one of the most promising, thanks to its ability to produce fibers of nanometric size. This manuscript aims to provide an overview to researchers approaching the field of repair and regeneration of tendons and ligaments. To clarify the general requirements of electrospun scaffolds, the first part of this manuscript presents a general overview concerning tendons’ and ligaments’ structure and mechanical properties. The different types of polymers, blends and particles most frequently used for tendon and ligament tissue engineering are summarized. Furthermore, the focus of the review is on describing the different possible electrospinning setups and processes to obtain different nanofibrous structures, such as mats, bundles, yarns and more complex hierarchical assemblies. Finally, an overview concerning how these technologies are exploited to produce electrospun scaffolds for tendon and ligament tissue applications is reported together with the main findings and outcomes.

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“…The scaffolds mimic the mechanical properties closely. [190] PCL and Gelatin halloysite nanotubes Acetic acid Wound healing applications Needle-less and free liquid surface electrospinning was used to fabricate uniform mats. Addition of halloysite nanotubes helped in increasing the mechanical properties of the scaffold.…”

Section: Tendon and Ligament Regenerationmentioning

confidence: 99%

Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering

Hanumantharao

Rao

2019

Fibers

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Electrospinning and polymer blending have been the focus of research and the industry for their versatility, scalability, and potential applications across many different fields. In tissue engineering, nanofiber scaffolds composed of natural fibers, synthetic fibers, or a mixture of both have been reported. This review reports recent advances in polymer blended scaffolds for tissue engineering and the fabrication of functional scaffolds by electrospinning. A brief theory of electrospinning and the general setup as well as modifications used are presented. Polymer blends, including blends with natural polymers, synthetic polymers, mixture of natural and synthetic polymers, and nanofiller systems, are discussed in detail and reviewed.

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Enhanced biological properties of biomimetic apatite fabricated polycaprolactone/chitosan nanofibrous bio-composite for tendon and ligament regeneration

Cited by 56 publications

References 31 publications

Current Progress in Tendon and Ligament Tissue Engineering

Current Progress in Tendon and Ligament Tissue Engineering

Biofabrication of Electrospun Scaffolds for the Regeneration of Tendons and Ligaments

Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering

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