Enhanced biocompatibility and adhesive properties of modified allyl 2-cyanoacrylate-based elastic bio-glues

Lim, Jong In; Kim, Ji Hye

doi:10.1016/j.colsurfb.2015.05.004

Cited by 16 publications

(6 citation statements)

References 24 publications

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“…To solve this problem, researchers improved the biocompatibility by optimizing cyanoacrylate so that it could be further used in clinical practice. At present, cyanoacrylate adhesives commonly used in clinics are octyl 2-cyanoacrylate and butyl 2-cyanoacrylate (García Cerdá et al, 2015;Lim and Kim, 2015;Kiaii et al, 2022).…”

Section: Cyanoacrylatementioning

confidence: 99%

Using extracellular matrix as the bio-glue for wound repair in the surgery

Zhou

Tang

Mei

et al. 2022

Front. Biomater. Sci.

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Bio-glues are gaining ground in medical research to close wounds and fight infections. Among them, the most promising bio-glue is the one prepared from natural materials (fibrin, gelatin, polysaccharides, etc.). Most of these materials are components of the extracellular matrix (ECM) and possess excellent biocompatibility, biodegradability and mechanical strength, which facilitate wound repair. However, there are no studies that utilize the decellularized materials to prepare bio-glues. Outside the wound sealants, approaches that utilize the ECM scaffold to promote tissue repair show tremendous potential. Experimentally, it is unknown if ECM can be successfully transformed to the bio-glue, either alone or in combination with nature biomaterials. In this review, we outline the first attempts at the potential of using ECM to prepare bio-glue for wound repair during the surgery.

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Section: Cyanoacrylatementioning

confidence: 99%

Using extracellular matrix as the bio-glue for wound repair in the surgery

Zhou

Tang

Mei

et al. 2022

Front. Biomater. Sci.

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“…In order to improve the biocompatibility and mechanical properties of cyanoacrylates, Lim et al mixed cyanoacrylate with poly- l -DOPA [ 120 ] in order to improve the physiochemical properties of cyanoacrylate for use as tissue glue. Lim and Kim also proposed to mix the cyanoacrylate component with poly( l -lactide- co -caprolactone) to obtain a biodegradable elastomer [ 121 ]. They reported that, although the adhesive strength was decreased compared to a pure cyanoacrylate compound, the biocompatibility and flexibility were improved.…”

Section: Current Developments In the Field Of Tissue Adhesivesmentioning

confidence: 99%

Tissue adhesives for meniscus tear repair: an overview of current advances and prospects for future clinical solutions

Bochynska

Hannink

Grijpma

et al. 2016

J Mater Sci: Mater Med

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Menisci are crucial structures in the knee joint as they play important functions in load transfer, maintaining joint stability and in homeostasis of articular cartilage. Unfortunately, ones of the most frequently occurring knee injuries are meniscal tears. Particularly tears in the avascular zone of the meniscus usually do not heal spontaneously and lead to pain, swelling and locking of the knee joint. Eventually, after a (partial) meniscectomy, they will lead to osteoarthritis. Current treatment modalities to repair tears and by that restore the integrity of the native meniscus still carry their drawbacks and a new robust solution is desired. A strong tissue adhesive could provide such a solution and could potentially improve on sutures, which are the current gold standard. Moreover, a glue could serve as a carrier for biological compounds known to enhance tissue healing. Only few tissue adhesives, e.g., Dermabond® and fibrin glue, are already successfully used in clinical practice for other applications, but are not considered suitable for gluing meniscus tissue due to their sub-optimal mechanical properties or toxicity. There is a growing interest and research field focusing on the development of novel polymer-based tissue adhesives, but up to now, there is no material specially designed for the repair of meniscal tears. In this review, we discuss the current clinical gold standard treatment of meniscal tears and present an overview of new developments in this field. Moreover, we discuss the properties of different tissue adhesives for their potential use in meniscal tear repair. Finally, we formulate recommendations regarding the design criteria of material properties and adhesive strength for clinically applicable glues for meniscal tears.

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“…Several types of alkyl cyanoacrylate adhesives are now being sold as retail and industrial adhesives globally [9]. However, numerous studies have shown that traditional cyanoacrylate is used only as a temporary adhesive due to its poor mechanical properties and local tissue toxicity [10,11]. Alkyl octyl cyanoacrylate adhesives with a side chain of eight carbon atoms have exhibited themselves as significant advances in terms of mechanical properties in the field of wound closure adhesive materials [12].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity and Cytotoxicity of Prepolymer Allyl 2-cyanoacrylate and 2-Octyl Cyanoacrylate Mixture Adhesives for Topical Wound Closure

Oh¹,

Hahm

Choi³

2023

Materials

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The development of a new skin adhesive that can be used inside and outside the body, which prevents infection and has fewer scars and less side effects, is currently attracting attention from the scientific community. To improve biocompatibility, prepolymer allyl 2-cyanoacrylate (PAC) and 2-octyl cyanoacrylate (OC) were mixed in various proportions and tested for their therapeutic potential as skin adhesives. A series of skin adhesive samples prepared by mixing PAC, OC, and additives with % (w/w) ratios of 100:0:0, 0:100:0, 70:0:30, 40:30:30, and 30:40:30 were tested to determine their antimicrobial activity, cell cytotoxicity, and formaldehyde release. The additives include myristic acid and dibutyl sebacate as plasticizers and butylated hydroxyanisole as an antioxidant. It was observed that the samples containing 70% PAC (PAC7) or 40% PAC (PAC4) with 30% additives had the highest antimicrobial activities against various microbial cells and no cytotoxicity regarding in vitro fibroblast cell growth. In addition, these formulations of adhesive samples released formaldehyde within the levels permitted for medical devices. Taken together, the mixture of PAC and OC as a topical skin adhesive for wound closure was found to be biocompatible, mechanically stable and safe, as well as effective for wound healing.

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Enhanced biocompatibility and adhesive properties of modified allyl 2-cyanoacrylate-based elastic bio-glues

Cited by 16 publications

References 24 publications

Using extracellular matrix as the bio-glue for wound repair in the surgery

Using extracellular matrix as the bio-glue for wound repair in the surgery

Tissue adhesives for meniscus tear repair: an overview of current advances and prospects for future clinical solutions

Antimicrobial Activity and Cytotoxicity of Prepolymer Allyl 2-cyanoacrylate and 2-Octyl Cyanoacrylate Mixture Adhesives for Topical Wound Closure

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