Enhanced bioavailability of piroxicam via salt formation with ethanolamines

Single-Step Preparation and Deagglomeration of Itraconazole Microflakes by Supercritical Antisolvent Method for Dissolution Enhancement

“…1 If the dissolution rate of these compounds can be enhanced, bioavailability following oral administration may be significantly improved. 2 Different approaches to enhance the dissolution rate of poorly soluble drugs include, but are not limited to, particle size reduction, [3][4][5][6] inclusion complexation with cyclodextrins, [7][8][9][10] solid dispersion, [11][12][13][14] salt formation, [15][16][17] use of surfactants, [18][19][20][21][22] cosolvency, [23][24] and various Improvement in bioavailability after micronization has been well documented for many drugs. 4,5,30,31 Micronization increases the dissolution rate of the drugs through increased surface area.…”

Simultaneous determination of positive and negative pharmaceutical counterions using mixed-mode chromatography coupled with charged aerosol detector

“…These properties can further improve the biological effects such as pharmacodynamics and pharmacokinetics, including bioavailability and toxicity profile [6,7]. According to the Orange Book database published by the U.S. Drug and Food Administration (FDA), among the 1356 API (Active Pharmaceutical Ingredient) approved by FDA up to the end of 2006, 51.4% are in salt forms, with 38.6% formed from basic molecules and 12.8% formed from acidic molecules [8,9].…”

Novel piroxicam-loaded nanospheres generated by the electrospraying technique: physicochemical characterisation and oral bioavailability evaluation

“…Particularly, when compared with the piroxicam powder, the plasma concentrations of piroxicam-loaded electrosprayed nanospheres were significantly higher (p < 0.05) until 24 h. Table 1 represents the pharmacokinetic parameters. It was observed that the AUC value of electrosprayed nanosphere was significantly higher in comparison to piroxicam powder (572.40 ± 204.36 vs. 175.80 ± 90.55 h.lg/ml; p < 0.05), indicating that the electrosprayed nanospheres gave about 3-fold higher AUC value than did the piroxicam powder (Gwak et al, 2005;Piao et al, 2008). However, the other pharmacokinetic parameters, such as T max , t 1/2 , K el , MRT, Cl/F and V z /F values of electrosprayed nanospheres were not significantly different compared to piroxicam powder.…”