Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study

Beyond the flavor: A green formulation of Ferula asafoetida oleo-gum-resin with fenugreek dietary fibre and its gut health potential

“…Uniform impregnation of the lipophilic gum into the hydrophilic matrix of dietary fibre gel, gave taste and odour masked Asafin particles for oral delivery. Gum like-character, high viscosity, encapsulating effect, mucoadhesive and gastroretentive properties of fenugreek galactomannans have already been reported as a good natural polymer suitable for oral delivery formulations [15] . Relatively high fibre content and also water based process without using any synthetic excipients or organic solvents make it suitable for nutraceutical and food applications.…”

“…Fenugreek soluble fibre was characterized as galactomannans and has been clinically shown to possess hypoglycemic, hypolipidemic and gastroprotective effects [13] , [14] . Earlier we had reported enhanced bioavailable formulations of curcumin using fenugreek galactomannans [15] .…”

Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

“…A number of formulations have utilized various techniques to decrease particle size as incorporation of curcumin in: liquid droplet nano-micelles containing lauroyl polyoxy 32-glycerides (Gelucire ® ) and polysorbate 20 (BioCurc ® ) [15]; fenugreek-derived galactomannan fiber (CurQfen ® ) [28]; liquid droplets containing Gelucire ® and caprylocaproyl polyoxyglycerides (Labrasol ® ), a BioCurc ® formulation [29]; colloidal dispersions using ghatti gum and glycerin (Theracurmin ® ) [30][31][32][33]; a matrix of glycerol esters of fatty acids, medium chain triglycerides, hydroxymethylcellulose and sodium alginate (MicroActive Curcumin®) [34]; a proprietary mixture of surfactants, polar lipids and solvents (HydroCurc ® ) [35]; solid lipid curcumin particles composed of docosahexaenoic acid (DHA), soy lecithin, stearic acid and vitamin C esters (Longvida ® ) [36]; a blend of sodium caseinate and Tween 20 [37]; proprietary microcapsules (Curcushine™); and a complex with acacia gum, quillaia (high in saponins) and sunflower oil (TurmiPure ® ).…”

“…Various pharmacokinetic studies have compared absorption between a formulated product and unformulated curcumin [15,[24][25][26][27][28]30,31,33] where enzymatic hydrolysis of plasma samples was employed, and therefore total curcumin but not free, bioactive curcumin was reported. Under these conditions, some indication of enhanced absorption is provided as a result of the product designed to enhance bioavailability.…”

Curcumin‐galactomannosides mitigate alcohol‐induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin

“…Commercial‐grade natural unformulated curcuminoids (standard curcumin) with 95.1% purity and CGM containing 38.6% curcuminoids, manufactured in a GMP (good manufacturing practices) facility were obtained from M/s Akay Flavours & Aromatics Pvt Ltd (Cochin, India). Total curcuminoids content as a sum of curcumin, demethoxycurcumin (DMC) and bis‐demethoxycurcumin (BDMC), was estimated by a validated high‐performance liquid chromatography (HPLC) method as reported earlier . Shimadzu M20 model HPLC fitted with photodiode array detector (Shimadzu Analytical India Pvt Ltd, Mumbai, India) and reverse‐phase C18 column (250 × 4.6 mm, 3 μm) (Phenomenex, Hyderabad, India) was used for the analysis.…”