Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone

Abstract

Although polyetheretherketone (PEEK) has been considered as a potential orthopedic and dental application material due to its similar elastic modulus as bones, inferior osseointegration and bacteriostasis of PEEK hampers its clinical application. In this work, fluorinated PEEK was constructed via plasma immersion ion implantation (PIII) followed by hydrofluoric acid treatment to ameliorate the osseointegration and antibacterial properties of PEEK. The surface microstructure, composition, and hydrophilicity of all samples were investigated. Rat bone mesenchymal stem cells (rBMSCs) were cultured on their surfaces to estimate bioactivity. The fluorinated PEEK can enhance the cell adhesion, cell spreading, proliferation, and alkaline phosphatase (ALP) activity compared to pristine PEEK. Furthermore, the fluorinated PEEK surface exhibits good bacteriostatic effect against Porphyromonas gingivalis, which is one of the major periodontal pathogens. In summary, we provide an effective route to introduce fluorine and the results reveal that the fluorinated PEEK can enhance the osseointegration and bacteriostasis, which provides a potential candidate for dental implants.

PEEK materials as an alternative to titanium in dental implants: A systematic review

“…Finally, 54 articles were included in present systematic review. Detailed data of the incorporated studies are listed as: 36 invitro studies in Table and 18 invivo studies in Table on PEEK material to find its efficacy as dental implant material .…”

“…Fluorinated PEEK was made by plasma immersion ion implantation (PIII) and enhanced rBMSCs adherence, cell spreading, multiplication, and ALP activity was found in comparison to pristine PEEK. It has superior bacteriostatic result against periodontal pathogens, Porphyromonas gingivalis . Functionalization of PEEK was done by sulphonation treatment to incorporate unique lactam‐based antibiofilms compounds so as to and found a better substitute for the creation of biomaterials resistance to bacterial contamination.…”

Silver-modified porous polystyrene sulfonate derived from Pickering high internal phase emulsions for capturing lithium-ion

“…Thus, it could be concluded that PHIPEs-SS-Ag had good regeneration ability for the selective capture of Li + . The antimicrobial activity of PHIPEs-SS and PHIPEs-SS-Ag, detecting against the model E. coli bacterial strains by forming a zone of inhibition, 44 suggested that PHIPEs-SS-Ag possessed antibacterial performance, which was benecial for the antifouling process ( Fig. 11).…”

Graphene‐Oxide‐Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant

“…Such a closed elastic modulus between the PEEK and human bones can mitigate the risks of osteanabrosis and bone resorption caused by stress shielding. [5,6] From the processing perspective, PEEK can be easily fabricated through conventional plastic processing, repeatedly sterilized and heated contouring to fit the shape of bones owing to the thermoplasticity. [7] In addition to these excellent characteristics, PEEK possesses good chemical resistance, nontoxicity, natural radiolucency, and magnetic resonance imaging compatibility.…”