1990
DOI: 10.1016/0165-1161(90)90043-n
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Enhanced assays detect increased chromosome damage and sister-chromatid exchanges in heroin addicts

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Cited by 12 publications
(3 citation statements)
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“…(24,25). Previously, various investigators reported that morphine enhances DNA damage in lymphocytic cells (37)(38)(39). These investigators suggest that opiates might be either decreasing the capacity to repair the damaged DNA or enhancing sensitization for DNA damage (37)(38)(39).…”
Section: Discussionmentioning
confidence: 99%
“…(24,25). Previously, various investigators reported that morphine enhances DNA damage in lymphocytic cells (37)(38)(39). These investigators suggest that opiates might be either decreasing the capacity to repair the damaged DNA or enhancing sensitization for DNA damage (37)(38)(39).…”
Section: Discussionmentioning
confidence: 99%
“…Also, Shafer et al 20 demonstrated by Comet assay that while brief ethyl methansulphonate exposure can be repaired by human cell cultures, if morphine exposures persists through one or more cell cycles, direct or indirect mutagenesis is initiated. Indeed, they had previously showed chromosomal aberrations in heroin addicts 21 …”
Section: Comet Assay: Principles and Applicationsmentioning
confidence: 99%
“…Indeed, they had previously showed chromosomal aberrations in heroin addicts. 21 The alkaline version of the Comet assay has been used to evaluate the possible genotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in mouse brain cells. 22 Data obtained in our lab indicated that MDMA was able to induce DNA fragmentation and oxidized bases to monoaminergic as well as non-monoaminergic neurons in the nigrostriatal pathway, indicating a final common pathway involving the generation of free radicals and oxidative stress.…”
Section: Comet Assay: Principles and Applicationsmentioning
confidence: 99%