Enhanced arachidonic acid metabolism in alveolar macrophages from wheezy infants. Modulation by dexamethasone.

Azevedo, Inês; Blic, J. de; Scheinmann, P.; Vargaftig, B. Boris; Bachelet, Maria

doi:10.1164/ajrccm.152.4.7551372

Cited by 48 publications

(32 citation statements)

References 26 publications

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“…Evidence for an increased release of eicosanoids by AMs in adults with asthma is provided by the studies of CHANEZ et al [4] and DAMON et al [5]. In a previous study, we showed that AMs from wheezy infants also spontaneously release increased amounts of eicosanoids, when compared to control children [6].…”

mentioning

confidence: 61%

“…The total number of nucleated cells was 0.38×10 6 (0.28×10 6 -0.41×10 6 ) cells·mL BAL -1 in wheezy children and 0.30×10 6 (0.23×10 6 -0.42×10 6 ) cells·mL BAL -1 in control children (NS). The viability of BAL cells was similar in both wheezy and control children (72 (68-79) % versus 74 (66-77) %; NS) and epithelial cells were always nonviable.…”

Section: Flexible Bronchoscopy and Bronchoalveolar Lavagementioning

confidence: 91%

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Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants

Azevedo

Blic²,

Dumarey³

et al. 1997

Eur Respir J

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mentioning

confidence: 61%

Section: Flexible Bronchoscopy and Bronchoalveolar Lavagementioning

confidence: 91%

Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants

Azevedo

Blic²,

Dumarey³

et al. 1997

Eur Respir J

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“…Furthermore, young asthmatic children had increased activated macrophages that released pro-inflammatory mediators (e.g. thromboxan B2, leukotriene-B4 and tumour necrosis factor-a) [41,42]. Protease anti-protease balance may also be altered in asthmatic airways: BALF concentrations of matrix metalloprotease (MMP)9 and tissue inhibitor of metalloprotease (TIMP)1 were found increased [43] or decreased [44] in asthmatic children and positive correlation was reported between MMP9/TIMP1 and nitric oxide output [44].…”

Section: Balfmentioning

confidence: 99%

Update on the roles of distal airways in asthma

Burgel¹,

Blic²,

Chanez³

et al. 2009

European Respiratory Review

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The present review is the summary of an expert workshop that took place in Vence (France) in 2007 on the role of distal airways in asthma. The evidence showing inflammation and remodelling in distal airways, and their possible involvement in asthma control and natural history, was reviewed. The usefulness and limitations of various techniques used for assessing distal airways were also evaluated, including pulmonary function tests and imaging. Finally, the available data studying the benefit of treatment better targeting distal airways in asthma was examined. It was concluded that both proximal and distal airways were involved in asthma and that distal airways were the major determinant of airflow obstruction. Inflammation in distal airways appeared more intense in severe and uncontrolled asthma. Distal airways were poorly attained by conventional aerosol of asthma medications owing to their granulometry, being composed of 3-5 mm particles. Both proximal and distal airways might be targeted either by delivering medications systemically or by aerosol of extra-fine particles. Extra-fine aerosols of long-acting b-agonists, inhaled corticosteroids or inhaled corticosteroid/long-acting b-agonist combinations have been shown in short-term studies to be not inferior to non-extra-fine aerosols of comparators. However, available studies have not yet demonstrated that extra-fine inhaled medications offer increased benefit compared with usual aerosols in asthmatic patients.

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“…This raises several essential questions such as when does asthma start and can patterns of progression towards persistent disease be individualized? To answer these questions, BAL is likely to represent a useful tool in wheezing infants by documenting the patterns of inflammatory marker expression at various stages of the disease [135,136].…”

Section: Identification Of At-risk Patients To Develop Respiratory DImentioning

confidence: 99%

Bronchoalveolar lavage in children

Blic¹,

Midulla²,

Barbato³

et al. 2000

eur respir j

350

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Bronchoalveolar lavage (BAL) is routinely performed in adults for sampling cellular and biochemical components. Many studies have been performed that have enabled the proposal of recommendations for BAL, methodology and processing, as well as reference values in different clinical settings. In contrast, despite a world-wide increase in the use of BAL in children, including neonates, there are, at the present time, no clear recommendations on the methodology, the clinical applications and the research areas for BAL. A Task Force on BAL in children has been approved by the European Respiratory Society (ERS) Task Force committee 1996. The objectives of this task force were: 1) to provide recommendations and guidelines on how to perform BAL and how to process the return fluid in children; 2) to collect and discuss available reference values; 3) to list indications and results in both immunocompetent and immunocompromised children; 4) to define areas for future research.This task force included paediatric respiratory physicians involved in bronchoscopy and BAL and was run as a collaboration between the Paediatric Bronchology Group and the BAL scientific group of the ERS.

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Enhanced arachidonic acid metabolism in alveolar macrophages from wheezy infants. Modulation by dexamethasone.

Cited by 48 publications

References 26 publications

Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants

Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants

Update on the roles of distal airways in asthma

Bronchoalveolar lavage in children

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